Advances in Peptic Ulcer Pathogenesis

  • W. D. W. Rees

Table of contents

  1. Front Matter
    Pages i-xi
  2. A. Sonnenberg, A. Sengupta, P. Bauerfeind
    Pages 1-31
  3. M. J. S. Langman
    Pages 81-100
  4. B. J. Rathbone, J. I. Wyatt, R. V. Heatley
    Pages 101-119
  5. L. A. Sellers, A. Allen
    Pages 121-144
  6. B. J. R. Whittle, J. L. Wallace
    Pages 183-203
  7. P. E. O’brien
    Pages 205-223
  8. Back Matter
    Pages 239-244

About this book


Over the past decade a great deal of research activity has occurred on either side of the gastroduodenal epithelial interface, with the common goal of elucidating the mechanisms of mucosal protection and how these may be compromised in peptic ulcer disease. A prime stimulus to such research has been the realization that abnormal acid secretion or its delivery into the duodenum in excessive amount cannot fully explain ulcer pathogenesis in the majority of patients. One may envisage the stomach and proximal duodenum as being in a dynamic equilibrium, with aggressive luminal factors, such as acid and pepsin, being counteracted by protective mucosal mechanisms. Until recently, the mechanisms involved in mucosal protection had been poorly defined while the physiology and pathophysiology of acid and pepsin secretion had been elucidated. The impression that gastroduodenal mucosa was protected by a single mechanism has at last been replaced by a more realistic view, suggesting a number of protective zones acting in series. Some of these zones may act as first or second line defences against aggressive factors while certain zones may specifically protect against certain aggressors.


bacteria epidemiology inflammation pathogenesis pathophysiology patients physiology research stomach

Editors and affiliations

  • W. D. W. Rees
    • 1
  1. 1.Department of GastroenterologyHope HospitalSalfordUK

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 1988
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-7052-2
  • Online ISBN 978-94-009-1245-8
  • Buy this book on publisher's site