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  • © 2013

Interrelations between Essential Metal Ions and Human Diseases

  • Up-to-date review on the relationships between essential metals and human diseases

  • Covers the bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium. Also covered are chromium, vanadium, nickel, silicon, and arsenic

  • Insight into metal homeostasis and role for life, including deficiency or overload, and the links of metals to illnesses, including cancer and neurological disorders

  • Includes supplementary material: sn.pub/extras

Part of the book series: Metal Ions in Life Sciences (MILS, volume 13)

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xxxvii
  2. Sodium and Potassium in Health and Disease

    • Hana R. Pohl, John S. Wheeler, H. Edward Murray
    Pages 29-47
  3. Magnesium in Health and Disease

    • Andrea M. P. Romani
    Pages 49-79
  4. Calcium in Health and Disease

    • Marisa Brini, Denis Ottolini, Tito Calì, Ernesto Carafoli
    Pages 81-137
  5. Vanadium. Its Role for Humans

    • Dieter Rehder
    Pages 139-169
  6. Manganese in Health and Disease

    • Daiana Silva Avila, Robson Luiz Puntel, Michael Aschner
    Pages 199-227
  7. Iron: Effect of Overload and Deficiency

    • Robert C. Hider, Xiaole Kong
    Pages 229-294
  8. Cobalt: Its Role in Health and Disease

    • Kazuhiro Yamada
    Pages 295-320
  9. Nickel and Human Health

    • Barbara Zambelli, Stefano Ciurli
    Pages 321-357
  10. Copper: Effects of Deficiency and Overload

    • Ivo Scheiber, Ralf Dringen, Julian F. B. Mercer
    Pages 359-387
  11. Zinc and Human Disease

    • Wolfgang Maret
    Pages 389-414
  12. Molybdenum in Human Health and Disease

    • Guenter Schwarz, Abdel A. Belaidi
    Pages 415-450
  13. Silicon: The Health Benefits of a Metalloid

    • Keith R. Martin
    Pages 451-473
  14. Selenium. Role of the Essential Metalloid in Health

    • Suguru Kurokawa, Marla J. Berry
    Pages 499-534
  15. Back Matter

    Pages 535-573

About this book

MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.

Reviews

From the book reviews:

“This volume, which lies at the natural juncture between chemistry, biology, physiology, biochemistry, pharmacology and medicine, provides the basis for understanding the important roles played by metal ions and the clinical consequences of an imbalance in their homeostasis. I have no doubt that this volume will serve not only as a source of inspiration as well as an important reference point for academics working in this research field, but will also act as an invaluable resource for undergraduate teaching.” (Celine J. Marmion, Transition Metal Chemistry, Vol. 39, 2014)

“The book is a great compilation of high-quality review articles describing how essential metals and metalloids correlate with human diseases. Its interdisciplinary line-up ensures that every reader will learn something new when browsing through the book. Each of its chapters is well suited to serve both as a reference for scientists already familiar with the respective subject and as a starting point for novices. … deserves a place in every scientific library and on the shelf of every bioinorganic chemist.” (Jens Müller, Inorganica Chimica Acta, Vol. 423, 2014)

Editors and Affiliations

  • Dept. of Chemistry, Inorganic Chemistry, University of Basel, Basel, Switzerland

    Astrid Sigel

  • Department of Chemistry, Inorganic Chemistry, University of Basel, Basel, Switzerland

    Helmut Sigel

  • Institute of Inorganic Chemistry, University of Zürich, Zürich, Switzerland

    Roland K.O. Sigel

Bibliographic Information

  • Book Title: Interrelations between Essential Metal Ions and Human Diseases

  • Editors: Astrid Sigel, Helmut Sigel, Roland K.O. Sigel

  • Series Title: Metal Ions in Life Sciences

  • DOI: https://doi.org/10.1007/978-94-007-7500-8

  • Publisher: Springer Dordrecht

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media Dordrecht 2013

  • Hardcover ISBN: 978-94-007-7499-5Published: 10 February 2014

  • Softcover ISBN: 978-94-024-0271-1Published: 17 September 2016

  • eBook ISBN: 978-94-007-7500-8Published: 27 January 2014

  • Series ISSN: 1559-0836

  • Series E-ISSN: 1868-0402

  • Edition Number: 1

  • Number of Pages: XXXVII, 573

  • Number of Illustrations: 75 b/w illustrations, 28 illustrations in colour

  • Topics: Life Sciences, general, Biomedicine general, Chemistry/Food Science, general

Buy it now

Buying options

eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access