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Cilia and Nervous System Development and Function

  • Kerry L. Tucker
  • Tamara Caspary

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Laura E. Mariani, Tamara Caspary
    Pages 55-82
  3. Evangelia Tasouri, Marc August Willaredt, Kerry L. Tucker
    Pages 83-104
  4. Matthew R. Sarkisian, Jon I. Arellano, Joshua J. Breunig
    Pages 105-129
  5. Cynthia M. Grimsley-Myers, Ping Chen
    Pages 131-163
  6. Nicolas F. Berbari, Raymond C. Pasek, Bradley K. Yoder
    Pages 165-191
  7. Shirui Hou, Young-Goo Han
    Pages 209-228
  8. Back Matter
    Pages 275-277

About this book

Introduction

Cilia are tiny microtubule-based organelles projecting from the plasma membrane of practically all cells in the body. In the past 10 years a flurry of research has indicated a crucial role of this long-neglected organelle in the development and function of the central nervous system. A common theme of these studies is the critical dependency of signal transduction of the Sonic hedgehog, and more recently, Wnt signaling pathways upon cilia to regulate fate decisions and morphogenesis. Both primary and motile cilia also play crucial roles in the function of the nervous system, including the primary processing of sensory information, the control of body mass, and higher functions such as behavior and cognition, serving as "antennae" for neurons to sense and  process their environment. In this book we describe the structure and function of cilia and the various tissues throughout the brain and spinal cord that are dependent upon cilia for their proper development and function.

Keywords

Brain function Cilia Obesity Sonic hedgehog Wnt signaling

Editors and affiliations

  • Kerry L. Tucker
    • 1
  • Tamara Caspary
    • 2
  1. 1., Anatomy and Cell BiologyUniversity of HeidelbergHeidelbergGermany
  2. 2., Human GeneticsEmory UniversityAtlantaUSA

Bibliographic information