GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity

  • Denis J. Dupré
  • Terence E. Hébert
  • Ralf Jockers
Part of the Subcellular Biochemistry book series (SCBI, volume 63)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Christian Nanoff, Michael Freissmuth
    Pages 1-21
  3. Denis J. Dupré, Maha M. Hammad, Patrick Holland, Jaime Wertman
    Pages 23-42
  4. Kathleen Van Craenenbroeck
    Pages 43-65
  5. Darlaine Pétrin, Terence E. Hébert
    Pages 67-81
  6. Barry M. Willardson, Christopher M. Tracy
    Pages 131-153
  7. Philip B. Wedegaertner
    Pages 193-223
  8. Pascal Maurice, Abla Benleulmi-Chaachoua, Ralf Jockers
    Pages 225-240
  9. Guadalupe Maya-Núñez, Alfredo Ulloa-Aguirre, Jo Ann Janovick, P. Michael Conn
    Pages 263-289
  10. Back Matter
    Pages 291-299

About this book

Introduction

This book provides a broad survey of various topics pertaining to G protein coupled receptor (GPCR) assembly into specific signalling complexes, and the regulation of the events leading to this assembly. Throughout this book, we focus on one main area: GPCRs are involved in highly efficient and specific activation of signalling pathways; how are these signalling complexes assembled to generate such specificity? To address this issue, we need to understand how receptors and their signalling partners are synthesized, folded correctly and assembled in order to generate functional complexes. The effects of oligomerization on specificity and efficacy of signal transduction are also discussed. Once receptor complexes are assembled, how are they targeted to different intracellular sites and what controls the trafficking of GPCR signalling complexes? Finally, defects in synthesis, maturation or trafficking can alter functionality of GPCR signalling complexes; how can we manipulate these systems to normalize them functionally?  Therefore, the topics to be covered in this book are:

1) Molecular chaperones involved in regulating (quality control) of GPCR synthesis;
2) Assembly of signalling complexes, or subunits of the complex and their organization;
3) GPCR oligomerization;
4) GPCR trafficking;
5) Problems of trafficking: pharmacological chaperones to the rescue.

Keywords

Assembly Chaperone G protein coupled receptor Signaling Trafficking

Editors and affiliations

  • Denis J. Dupré
    • 1
  • Terence E. Hébert
    • 2
  • Ralf Jockers
    • 3
  1. 1.Faculty of Medicine, PharmacologyDalhousie UniversityHalifaxCanada
  2. 2., Pharmacology and TherapeuticsMcGill UniversityMontrealCanada
  3. 3.Institut CochinParisFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-4765-4
  • Copyright Information Springer Science+Business Media Dordrecht 2012
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-4764-7
  • Online ISBN 978-94-007-4765-4
  • Series Print ISSN 0306-0225
  • About this book