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Maternal Fetal Transmission of Human Viruses and their Influence on Tumorigenesis

  • György Berencsi III

Table of contents

  1. Front Matter
    Pages i-viii
  2. György Berencsi III, Maria Takács
    Pages 1-50
  3. Eva Ay, Ferenc Banati, Katalin Turi-Balog, Janos Minarovits
    Pages 83-104
  4. György Berencsi III, Márta Csire
    Pages 105-169
  5. Jesse H. Arbuckle, Shara Pantry, Peter G. Medveczky
    Pages 171-194
  6. Purnima Bhat
    Pages 195-222
  7. Hilmar Lemke, Radu I. Tanasa, Ahmad Trad, Hans Lange
    Pages 249-279
  8. György Berencsi III, Erzsébet Barcsay
    Pages 335-388
  9. Back Matter
    Pages 443-464

About this book

Introduction

The human foetus is separated from the maternal blood by the syncytiotrophoblast induced by endogeneous human retrovirus-encoded proteins. This barrier is a highly developed one, which suppors apical-basolateral transport of maternal idiotype and anti-idiotype IgG, IgG-virus complexes.

The selective maternal-fetal transport of epitope- and paratope-bearing entities can influence the developping fetal immune system during pregnancy.

The bidirectional maternal-fetal transfer of cells are of even more importance during pregnancy. Maternal cells with latent viruses transport viruses without impairment of fetal development. Cells with premaligant and malignant genetic transformation are also transported to the fetus. Fetal and neonatal tumours are initiated by such cells in spite of the antitumour potential of fetal organism. On the contary, the fetal cells repair maternal tissue injouries and survive in the organisms of the recipients for decades. These possess new consequences for the neonatal immunity and organ transplatation surgery.

Keywords

Bi-directional Microchimerism Maternal-fetal Transcitosis Pregnancy and Tumours Transgenerational Messenger Antibodies Vertical Transmission of HHV-6

Editors and affiliations

  • György Berencsi III
    • 1
  1. 1., Division of VirologyNational Center for EpidemiologyBudapestHungary

Bibliographic information