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  • © 2012

Interplay between Metal Ions and Nucleic Acids

  • Provides an up-to-date information on nucleic acid-metal ion interactions

  • Indicates future developments (nanotechnology) involving DNA and RNA

  • Valuable for teaching courses in Inorganic Biochemistry

  • Describes the analytical tools needed in nucleic acid chemistry

  • Describes comprehensively DNAzymes

  • Describes the technology of DNA

Part of the book series: Metal Ions in Life Sciences (MILS, volume 10)

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eBook USD 149.00
Price excludes VAT (USA)
  • ISBN: 978-94-007-2172-2
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 189.00
Price excludes VAT (USA)
Hardcover Book USD 279.99
Price excludes VAT (USA)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xxxiii
  2. Characterization of Metal Ion-Nucleic Acid Interactions in Solution

    • Maria Pechlaner, Roland K. O. Sigel
    Pages 1-42
  3. Nucleic Acid-Metal Ion Interactions in the Solid State

    • Katsuyuki Aoki, Kazutaka Murayama
    Pages 43-102
  4. G-Quadruplexes and Metal Ions

    • Nancy H. Campbell, Stephen Neidle
    Pages 119-134
  5. Metal Ion-Mediated DNA-Protein Interactions

    • Barbara Zambelli, Francesco Musiani, Stefano Ciurli
    Pages 135-170
  6. Spectroscopic Investigations of Lanthanide Ion Binding to Nucleic Acids

    • Janet R. Morrow, Christopher M. Andolina
    Pages 171-199
  7. Enantioselective Catalysis at the DNA Scaffold

    • Almudena García-Fernández, Gerard Roelfes
    Pages 249-268
  8. Alternative DNA Base Pairing through Metal Coordination

    • Guido H. Clever, Mitsuhiko Shionoya
    Pages 269-294
  9. Metal-Mediated Base Pairs in Nucleic Acids with Purine- and Pyrimidine-Derived Nucleosides

    • Dominik A. Megger, Nicole Megger, Jens Müller
    Pages 295-317
  10. Metal Complex Derivatives of Peptide Nucleic Acids (PNA)

    • Roland Krämer, Andriy Mokhir
    Pages 319-340
  11. Back Matter

    Pages 341-353

About this book

The Metal Ions in Life Sciences series links coordination chemistry and biochemistry in their widest sense and thus increases our understanding of the relationship between the chemistry of metals and life processes. The series reflects the interdisciplinary nature of Biological Inorganic Chemistry and coordinates the efforts of scientists in fields like biochemistry, inorganic and coordination chemistry, molecular and structural biology, enzymology, environmental chemistry, physiology, toxicology, biophysics, pharmacy, and medicine. Consequently, the volumes are an essential source for researchers active in these and related fields as well as teachers preparing courses, e.g., in Bioinorganic Chemistry.

MILS-10: Interplay between Metal Ions and Nucleic Acids provides in an authoritative and timely manner in 12 stimulating chapters, written by 24 internationally recognized experts from 8 nations, and supported by nearly 1500 references, about 20 tables, and 125 illustrations, many in color, a most up-to-date view on metal ion-nucleic acid interactions; the characterization of which is covered in solution and in the solid state. The volume concentrates on modern developments encompassing topics in the wide range from G-quadruplexes via DNAzymes, catalysis at the DNA scaffold, and metal-mediated base pairs to peptide nucleic acids (PNAs) being thus of relevance, e.g., for chemistry and nanotechnology but also for molecular biology and (genetic) diagnostics.

The Editors
Astrid Sigel, Helmut Sigel and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. They published on metal ion interactions with nucleotides and nucleic acids and on related topics, and edited previously 44 volumes in the series Metal Ions in Biological Systems.

Keywords

  • Biosensors
  • DNA
  • Peptide nucleic acids (PNA
  • RNA
  • metal ion-nucleic acid interactions

Reviews

From the reviews:

“Bioinorganic chemistry is an exciting branch of chemistry with applications in new materials (including sensors and tissues), health (diagnosis and therapy), energy supplies (generation and storage), biological function, evolution, and beyond. The Sigel volumes are always a reliable way of keeping abreast of this rapidly expanding field. This one is no exception. ... This book is a good read and all bioinorganic chemists might wish it was on their shelves—not only for research, but as a resource for undergraduate teaching” (Peter J. Sadler, Angewandte Chemie International Edition, Vol. 51, 2012)

“‘Interplay between Metal Ions and Nucleic Acids’ … is for the entire community of researchers interested in metal-nucleic acid interactions. Its contents are highly topical, as they cover numerous relevant areas of a research that faces rapid growth. Reading this volume is a ‘must’ for scientists active in this field, and the editors should be congratulated on the fine selection of chapters and authors. … volume10 of MILS is among the very best books on this subject that have appeared in recent years!” (Bernhard Lippert, Inorganica Chimica Acta,Vol. 394, January, 2013)

"This book will be an excellent companion to postgraduate students and established researchers interested in the essential role that metal ions play in the structure and function of nucleic acids. In addition, this volume will be of interest to scientists working towards the use of nucleic acids for sensing and catalytic applications, as well as for the development of novel nanomaterials." (Ramon Vilar, Transition Metal Chemistry, Vol. 37, 2012)

Editors and Affiliations

  • Inorganic Chemistry, Chemistry, Universität Basel, Basel, Switzerland

    Astrid Sigel, Helmut Sigel

  • Organisch-Chemisches Institut, Universität Zürich, Zürich, Switzerland

    Roland K. O. Sigel

Bibliographic Information

Buying options

eBook USD 149.00
Price excludes VAT (USA)
  • ISBN: 978-94-007-2172-2
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 189.00
Price excludes VAT (USA)
Hardcover Book USD 279.99
Price excludes VAT (USA)