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  • Book
  • © 2011

The Myelodysplastic Syndromes

Editors:

(view affiliations)
  • Updated patient stratification for the different therapeutical modalities

  • Updated disease classification

  • Update of the available therapies

  • Includes supplementary material: sn.pub/extras

Buying options

eBook
USD 179.00
Price excludes VAT (USA)
  • ISBN: 978-94-007-0440-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 229.99
Price excludes VAT (USA)
Hardcover Book
USD 279.99
Price excludes VAT (USA)

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Table of contents (16 chapters)

  1. Front Matter

    Pages 1-1
  2. Susceptibility to MDS: DNA Repai r and Detoxification Genes

    • Claire Seedhouse, Nigel Russell
    Pages 5-24
  3. Diagnostic Criteria and Classification of Myelodysplastic Syndromes

    • Peter Valent, Friedrich Wimazal, Wolfgang R. Sperr, Hans-Peter Horny
    Pages 43-53
  4. Cytogenetics of MDS

    • Detlef Haase, Christina Ganster, Christian Steidl, Katayoon Shirneshan, Friederike Braulke, Julie Schanz
    Pages 55-85
  5. Molecular Changes in Myelodysplastic Syndrome

    • Florian Nolte, Wolf-K. Hofmann
    Pages 87-101
  6. Prognostic Scoring in MDS

    • Michael Pfeilstöcker
    Pages 103-120
  7. Flow Cytometry in Myelodysplastic Syndromes

    • C. Alhan, T.M. Westers, G.J. Ossenkoppele, Arjan A. van de Loosdrecht
    Pages 121-143
  8. MDS as an Autoimmune Process

    • W. Ingram, Y. Kordasti, G. J. Mufti
    Pages 145-157
  9. The Myelodysplastic Overlap Syndromes

    • W. Ingram, G. J. Mufti
    Pages 159-173
  10. Iron and Copper Metabolism in the Myelodysplastic Syndromes

    • Judit Várkonyi, Gabriella Bekő, Zoltán Prohászka, István Karádi
    Pages 175-185
  11. Cytokines in MDS: Abnormalities and Treatment

    • Howard S. Oster, Drorit Neumann, Moshe Mittelman
    Pages 205-218
  12. Therapeutic Modalities and New Molecular Targets in MDS

    • Guillermo Garcia-Manero
    Pages 219-238
  13. Back Matter

    Pages 272-272

About this book

Myelodysplastic syndromes (MDS) are the most common hematological malignancies involving mostly the elderly population. The major morbidity relates to patients’ symptomatic cytopenias.MDS was previously named as  “preleukemia “ or “ smoldering leukemia” as the lack of terminal cells in MDS and because about 25% of all cases progresses into acute myeloid leukemia.

According to various reports the annual incidence of MDS ranges widely from 2-12 per 100.000, increasing to 30-50 cases per 100.000 among persons aged  70  or older. It is believed that the true incidence of MDS have been underestimated however it seems to be comparable to that for multiple myeloma and chronic lymphocytic leukemia.  

In the past decade much progress had been made; we know more on the disease pathology, there is more emphasis on the care and more targeted therapy had been invested.

Athors provide updated knowledge in this book on all clinically important aspects of the disease. Hot topics of our days are discussed in chapters by outstanding and well known scientists from all over the world. We would offer this product both for medical students and postgraduates as well as for all who are interested in this very exciting and fast progressing field of hematology.

With this work authors should call attention on the disease for decision makers in healt care systems as well.

 

Keywords

  • iron overload
  • myelodysplasia
  • refractory anemia
  • refractory cytopenia
  • targeted therapy

Editors and Affiliations

  • , 3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary

    Judit Várkonyi

Bibliographic Information

Buying options

eBook
USD 179.00
Price excludes VAT (USA)
  • ISBN: 978-94-007-0440-4
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 229.99
Price excludes VAT (USA)
Hardcover Book
USD 279.99
Price excludes VAT (USA)