Planning and Designing Clinical Research

  • S. B. Martins
  • W. A. Zin
Conference proceedings

Part of the Series Teaching and Training in Anaesthesiology and Critical Care book series (TEACHTRAINING, volume 1)

Table of contents

  1. Front Matter
    Pages I-IX
  2. S. B. Martins, W. A. Zin
    Pages 1-48
  3. Back Matter
    Pages 49-49

About these proceedings


This manuscript is an introduction to the design and planning of clinical research. Practical issues are covered with a theoretical background. The refinement of a research question, searching and critically appraising the literature and management of references are discussed. Ethical concerns are raised throughout the development of the study protocol. Study designs are described and special emphasis is given to writing a protocol of a clinical trial. Sample selection and recruitment, variable measurement, randomization, follow up, statistical analysis, sample size and bias are covered. Tips on how to successfully write and publish the research report are provided.


anesthesiology care intensive care pain planning

Authors and affiliations

  • S. B. Martins
    • 1
  • W. A. Zin
    • 2
  1. 1.Fellow in Health Services ResearchUniversity of California at San FranciscoSan FranciscoUSA
  2. 2.Laboratory of Respiration Physiology, Carlos Chagas Filho Biophysics InstituteFederal University of Rio de JaneiroRio de JaneiroBrasil

Bibliographic information