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Quorum Sensing vs Quorum Quenching: A Battle with No End in Sight

  • Vipin Chandra Kalia

Table of contents

  1. Front Matter
    Pages i-xi
  2. Vipin C. Kalia
    Pages 1-5
  3. Quorum Sensing Mediated Processes

    1. Front Matter
      Pages 7-7
    2. Ashima Kushwaha Bhardwaj, Kittappa Vinothkumar
      Pages 9-22
    3. Pragasam Viswanathan, Suneeva S. C., Prasanth Rathinam
      Pages 39-50
    4. Jie Gao, Anzhou Ma, Xuliang Zhuang, Guoqiang Zhuang
      Pages 51-60
    5. Navneet Rai, Rewa Rai, K. V. Venkatesh
      Pages 61-64
    6. Francisca Diana da Silva Araújo, Armando Mateus Pomini, Anita Jocelyne Marsaioli
      Pages 65-69
  4. Quorum Sensing Systems in Microbes

    1. Front Matter
      Pages 71-71
    2. Jamuna Bai Aswathanarayan, V. Ravishankar Rai
      Pages 73-84
    3. Nidhi Bhargava, Prince Sharma, Neena Capalash
      Pages 101-113
    4. Weihua Chu, Wei Zhu, Xiyi Zhuang
      Pages 115-121
    5. Charles Darkoh, Godfred Ameyaw Asiedu
      Pages 133-154
    6. Ravindra Pal Singh, Jiro Nakayama
      Pages 155-163
    7. Lalit K. Singh, Neha Dhasmana, Yogendra Singh
      Pages 165-170
  5. Detectors for Quorum Sensing Signals

    1. Front Matter
      Pages 171-171
    2. Navneet Rai, Rewa Rai, K. V. Venkatesh
      Pages 173-183
    3. Kristina Ivanova, Margarida M. Fernandes, Tzanko Tzanov
      Pages 197-216
  6. Natural Quorum Sensing Inhibitors

    1. Front Matter
      Pages 217-217
    2. Manuel Romero, Celia Mayer, Andrea Muras, Ana Otero
      Pages 219-236
    3. Rohit Sharma, Kamlesh Jangid
      Pages 237-257
    4. Fohad Mabood Husain, Iqbal Ahmad
      Pages 259-268
    5. Pragasam Viswanathan, Prasanth Rathinam, Suneeva S. C.
      Pages 269-281
  7. Synthetic Quorum Sensing Inhibitors

  8. Alternative Strategies as Quorum Sensing Inhibitors

    1. Front Matter
      Pages 325-325
    2. Prasun Kumar, Shikha Koul, Sanjay K. S. Patel, Jung-Kul Lee, Vipin C. Kalia
      Pages 343-356
  9. Biotechnological Applications of Quorum Sensing Inhibitors

    1. Front Matter
      Pages 357-357
    2. Faseela Hamza, Ameeta Ravi Kumar, Smita Zinjarde
      Pages 371-383

About this book

Introduction

Microbial relationships with all life forms can be as free living, symbiotic or pathogenic. Human beings harbor 10 times more microbial cells than their own. Bacteria are found on the skin surface, in the gut and other body parts. Bacteria causing diseases are the most worrisome. Most of the infectious diseases are caused by bacterial pathogens with an ability to form biofilm. Bacteria within the biofilm are up to 1000 times more resistant to antibiotics. This has taken a more serious turn with the evolution of multiple drug resistant bacteria. Health Departments are making efforts to reduce high mortality and morbidity in man caused by them. Bacterial Quorum sensing (QS), a cell density dependent phenomenon is responsible for a wide range of expressions such as pathogenesis, biofilm formation, competence, sporulation, nitrogen fixation, etc. Majority of these organisms that are important for medical, agriculture, aquaculture, water treatment and remediation, archaeological departments are:  Aeromonas, Acinetobacter, Bacillus, Clostridia, Enterococcus, Pseudomonas, Vibrio and Yersinia spp. Biosensors and models have been developed to detect QS systems. Strategies for inhibiting QS system through natural and synthetic compounds have been presented here. The biotechnological applications of QS inhibitors (QSIs) in diverse areas have also been dealt with. Although QSIs do not affect growth and are less likely to impose selective pressure on bacteria, however, a few reports have raised doubts on the fate of QSIs. This book addresses a few questions. Will bacteria develop mechanisms to evade QSIs? Are we watching yet another defeat at the hands of bacteria? Or will we be acting intelligently and survive the onslaughts of this Never Ending battle?

Keywords

Antibacterial agents Antipathogenic drugs Biofilm Biosensors Pathogenic bacteria

Editors and affiliations

  • Vipin Chandra Kalia
    • 1
  1. 1.CSIR-Institute of Genomics and Integrative BiologyMicrobial Biotechnology and GenomicsDelhiIndia

Bibliographic information