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About this book
How do you discriminate yourself from other people? This question must sound odd to you since you easily recognize others at a glance and, without any effort, would not mistake them for yourself. However, it is not always easy for some people to discriminate themselves from others. For example, patients with schi- phrenia often talk with “others” living inside themselves. Thus it is likely that n- mally your brain actively recognizes and remembers the information belonging to yourself and discriminates it from the information provided by others, although you are not conscious of it. This brain function must have been particularly important for most animals to protect their lives from enemies and for species to survive through evolution. Similarly, higher organisms have also acquired their immune system through evolution that discriminates nonself pathogens and self-body to protect their lives from pathogens such as bacteria or viruses. The brain system may distinguish integrated images of self and nonself created from many inputs, such as vision, sound, smell, and others. The immune system recognizes and distinguishes a variety of structural features of self and nonself components. The latter actually include almost everything but self: for example, bacteria, viruses, toxins, pollens, chemicals, transplanted organs, and even tumor cells derived from self-tissue. To this end the immune system recruits different kinds of immune cells, such as B and T lymphocytes, natural killer (NK) cells, dendritic cells, and macrophages.
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Table of contents (8 chapters)
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Front Matter
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Back Matter
Editors and Affiliations
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Bibliographic Information
Book Title: How the Immune System Recognizes Self and Nonself
Book Subtitle: Immunoreceptors and Their Signaling
Editors: Daisuke Kitamura
DOI: https://doi.org/10.1007/978-4-431-73884-8
Publisher: Springer Tokyo
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer-Verlag Tokyo 2008
Hardcover ISBN: 978-4-431-73883-1Published: 20 November 2007
Softcover ISBN: 978-4-431-99831-0Published: 21 October 2010
eBook ISBN: 978-4-431-73884-8Published: 08 April 2008
Edition Number: 1
Number of Pages: XVIII, 251
Number of Illustrations: 6 illustrations in colour
Topics: Immunology, Molecular Medicine, Medical Biochemistry, Cell Biology