Overview
- Editors:
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Eiichi Tahara
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Faculty of Medicine, First Department of Pathology, Hiroshima University School of Medicine, Minami-ku, Hiroshima 734, Japan
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Table of contents (17 chapters)
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Front Matter
Pages II-VIII
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- Hiroko Ohgaki, Takashi Sugimura
Pages 1-14
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- Yusuke Nakamura, Takashi Tokino, Minoru Isomura, Johji Inazawa, Takahisa Aoki, Takahiro Mori et al.
Pages 15-21
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- Pelayo Correa, Mark Miller, Elizabeth E. Mannick
Pages 23-29
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- Kazuhiro Yoshida, Wataru Yasui, Yoshihiro Kagawa, Eiichi Tahara
Pages 31-41
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- Atsushi Ochiai, Setsuo Hirohashi
Pages 43-53
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- Hiroshi Yokozaki, Hiroki Kuniyasu, Shuho Semba, Wataru Yasui, Eiichi Tahara
Pages 55-70
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- Reuben Lotan, Eiichi Tahara
Pages 71-80
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- Hisao Ito, Masato Ishida, Satoshi Ohfuji, Mitsuhiko Osaki, Hisae Hayashi, Shigeru Tatebe
Pages 81-92
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- Fumio Shimamoto, Shinji Tanaka, Eiichi Tahara
Pages 93-106
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- Kiyomi Taniyama, Naomi Sasaki, Hiroshi Maruyama, Hayao Nakai, Hirofumi Nakatsuka, Kazushige Toyama et al.
Pages 107-127
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- Wataru Yasui, Hiroshi Yokozaki, Eiichi Tahara
Pages 187-207
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- Libin Jia, Xin Wei Wang, Zongtang Sun, Curtis C. Harris
Pages 209-218
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- Christopher J. Bakkenist, James O’D. McGee
Pages 219-243
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- Hidetoshi Tahara, Eiji Tahara, Eiichi Tahara, Toshinori Ide
Pages 245-259
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Back Matter
Pages 261-267
About this book
Twenty years have passed since I became a professor in the First Department of Pathology, Hiroshima University School of Medicine. It is my great pleas ure that Molecular Pathology o[ Gastroenterological Cancer-Application to Clinical Practice has been published by Springer-Verlag Tokyo to commemo rate the 20th anniversary of my professorship. Seeing the academic achievements of our department during these 20 years, I am confident that we could establish a department of oncology to research the pathogenesis of human cancer through systemic application of a variety of molecular techniques. We have demonstrated that the develop me nt and progression of esophageal, gastric, and colon cancer require mul tiple alterations affecting DNA mismatch repair genes, oncogenes, and tumorsuppressor genes, and that common and uncommon genetic changes exist for esophageal, gastric, and colorectal carcinomas. In addition to these genetic changes, the majority of gastrointestinal cancers express telomerase activity, with overexpression of telomerase RNA, indicating a powerful addi tional tool for early detection of gastrointestinal cancer. By transferring these basic observations to the clinic, we now are able to make accurate cancer diagnoses, thus determing the grade of malignancy and patient prognosis. We also can identify patients at high risk for developing cancer and create new therapeutic approaches. In fact, we have routinely implemented a new molecular diagnosis strategy at the Hiroshima City Medi cal Association Clinical Laboratory since August 1993.
Editors and Affiliations
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Faculty of Medicine, First Department of Pathology, Hiroshima University School of Medicine, Minami-ku, Hiroshima 734, Japan
Eiichi Tahara