Photoaffinity Labeling for Structural Probing Within Protein

  • Yasumaru Hatanaka
  • Makoto Hashimoto

Table of contents

  1. Front Matter
    Pages i-viii
  2. Amberlyn M. Wands, Jennifer J. Kohler
    Pages 45-78
  3. Kohichi Kawahara, Katsuyoshi Masuda, Masaji Ishiguro, Hitoshi Nakayama
    Pages 79-92
  4. Gen Tanaka, Yoshimasa Kawaguchi, Keiko Kuwata, Toshihide Takeuchi, Ikuhiko Nakase, Shiroh Futaki
    Pages 225-240
  5. Hideyuki Muranaka, Takaki Momose, Chiaki Handa, Tomonaga Ozawa
    Pages 241-265

About this book

Introduction

This book covers the most up-to-date photoaffinity labeling method to tackle the key loop module involved in the binding process of a bioactive small molecule to its host protein. The book introduces rational points for preparing powerful photoaffinity probes, keys for the efficient analysis of labeled products, and recent successful applications for protein probing. Regarding drug design, the unique topics of the book are the special consideration of the crosslinking potential of recent probes and their application of important receptor proteins . This book presents emerging technologies of photoaffinity labeling to readers who are working in the fields of proteomics, molecular recognition, and drug discovery and development.

Keywords

Protein analysis Affinity-based profiling Membrane protein Bioactive molecule Ligand receptor Molecular recognition Binding site Photoactivatable probe Multifunctional probe Diazirine Carbene Cross-linking Drug discovery Chemical biology

Editors and affiliations

  • Yasumaru Hatanaka
    • 1
  • Makoto Hashimoto
    • 2
  1. 1.University of ToyamaToyamaJapan
  2. 2.Graduate School of AgricultureHokkaido UniversitySapporoJapan

Bibliographic information

  • DOI https://doi.org/10.1007/978-4-431-56569-7
  • Copyright Information Springer Japan KK 2017
  • Publisher Name Springer, Tokyo
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-4-431-56568-0
  • Online ISBN 978-4-431-56569-7
  • About this book