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Human iPS Cells in Disease Modelling

  • Keiichi Fukuda

Table of contents

  1. Front Matter
    Pages i-vii
  2. Tomohisa Seki, Shinsuke Yuasa, Keiichi Fukuda
    Pages 1-9
  3. Elena Matsa, Karim Sallam, Joseph C. Wu
    Pages 11-26
  4. K. Shah, C.-Y. Wei, C.-S. Kim, J. Wong, J.-Y. Wen, T. Tirasawasdichai et al.
    Pages 27-43
  5. Guang-Hui Liu, Jiping Yang, Zhichao Ding, Alejandro Ocampo, Jing Qu, Keiichiro Suzuki et al.
    Pages 53-67
  6. Megumu K. Saito, Akira Niwa
    Pages 69-81
  7. Charis-P. Segeritz, Ludovic Vallier
    Pages 83-99

About this book

Introduction

Human iPS cells have a great potential to be cell sources for regenerative medicine because of the promise of infinite self-renewal and the capability to differentiate into multiple cell types. This book focuses on another great potential of human iPS cells, which is the establishment of human disease models using patient-specific iPS cells. Human iPS cells can be easily obtained from a patient’s somatic cells and provide the entire information on the patient’s genome. Accordingly, we can generate disease models for inheritable diseases in cell culture dishes using iPS cells. This is a quite new technique but holds tremendous potential for our increased understanding of pathogenesis, and will then be the basis for novel drug development industries. All the authors are leading researchers in this field and they have reported many kinds of patient-derived iPS cells. In this book, they introduce the aspects that could be recapitulated in terms of disease modelling as well as further innovative findings such as novel pathogenetic insights and novel therapies. 

Keywords

cell reprogramming iPS cell iPSCs induced pluripotent stem cells stem cel biology ES cell disease modeling

Editors and affiliations

  • Keiichi Fukuda
    • 1
  1. 1.Keio University School of MedicineDepartment of CardiologyTokyoJapan

Bibliographic information