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Optogenetics

Light-Sensing Proteins and Their Applications

  • Hiromu Yawo
  • Hideki Kandori
  • Amane Koizumi

Table of contents

  1. Front Matter
    Pages i-ix
  2. Light-Sensing Proteins

    1. Front Matter
      Pages 1-1
    2. Mineo Iseki, Tetsuo Takahashi
      Pages 17-29
    3. Hideaki E. Kato, Ryuichiro Ishitani, Osamu Nureki
      Pages 31-45
    4. Takashi Kikukawa, Naoki Kamo, Makoto Demura
      Pages 47-62
    5. Akihisa Terakita, Takashi Nagata, Tomohiro Sugihara, Mitsumasa Koyanagi
      Pages 77-88
    6. Kota Katayama, Sivakumar Sekharan, Yuki Sudo
      Pages 89-107
  3. Optogenetics in Biological Systems

    1. Front Matter
      Pages 109-109
    2. Hiromu Yawo, Ryo Egawa, Shoko Hososhima, Lei Wen
      Pages 111-131
    3. Masamichi Ohkura, Junko Sadakari, Junichi Nakai
      Pages 133-147
    4. Ken Berglund, Lei Wen, George J. Augustine
      Pages 159-183
    5. Hiroshi Kohsaka, Akinao Nose
      Pages 199-212
    6. Yuki Tsukada, Ikue Mori
      Pages 213-226
  4. Optogenetics in Neuroscience

  5. Medical Optogenetics

  6. Optogenetics and Opto-electronics

    1. Front Matter
      Pages 373-373
    2. Takashi Tokuda, Toshihiko Noda, Kiyotaka Sasagawa, Jun Ohta
      Pages 375-389
  7. Back Matter
    Pages 405-409

About this book

Introduction

The subject of optogenetics is comprehensively covered in this book, including physical, chemical, and biological topics of light-sensing proteins and their application in biological systems, particularly in neuroscience and medicine and the related opto-electronics. Optogenetics is a new technology that combines genetics and optics. It enables one to manipulate or measure the function of identified cells or neurons in a tissue by light with an accuracy in the range of milliseconds, even in a freely moving animal. Optogenetics has already become a powerful tool for revealing the neural mechanisms underlying behavior and analyzing various physiological phenomena. It is also expected to become useful for treating neural dysfunctions such as Parkinson disease and for the development of a brain–machine interface. This book should be read by any scientist or student performing research in any way related to optogenetics. As a milestone publication on optogenetics, this book will serve as a compass for any researcher, from beginners to experts, to explore this uncharted world.

Keywords

Channelrhodopsin Halorhodopsin Neural circuits Optical sensors Psychiatry Visual prosthesis

Editors and affiliations

  • Hiromu Yawo
    • 1
  • Hideki Kandori
    • 2
  • Amane Koizumi
    • 3
  1. 1.Department of Developmental Biology and NeuroscienceTohoku University Graduate School of Life SciencesSendaiJapan
  2. 2.Department of Frontier MaterialsNagoya Institute of TechnologyNagoyaJapan
  3. 3.National Institutes of Natural SciencesTokyoJapan

Bibliographic information