Regenerative Medicine for the Inner Ear

  • Juichi Ito

Table of contents

  1. Front Matter
    Pages i-xi
  2. Targets of Regenerative Medicine for the Inner Ear

    1. Front Matter
      Pages 1-1
    2. Tatsunori Sakamoto, Harukazu Hiraumi
      Pages 3-13
    3. Norio Yamamoto
      Pages 23-30
    4. Tomoko Kita, Tatsuya Katsuno, Shin-ichiro Kitajiri
      Pages 31-38
    5. Takayuki Okano
      Pages 39-52
    6. Tetsuji Sekiya, Harukazu Hiraumi
      Pages 53-59
    7. Yosuke Tona, Akiko Taura
      Pages 67-74
    8. Yosuke Tona, Tatsunori Sakamoto
      Pages 75-80
  3. Development of the Inner Ear

    1. Front Matter
      Pages 81-81
    2. Norio Yamamoto
      Pages 83-90
    3. Hiroe Ohnishi, Tatsunori Sakamoto
      Pages 91-99
    4. Tomoko Tateya
      Pages 101-113
    5. Hiroko Torii, Akiko Taura
      Pages 115-125
  4. Cochlear Implants

    1. Front Matter
      Pages 127-127
    2. Hiroshi Yamazaki
      Pages 129-137
    3. Harukazu Hiraumi
      Pages 139-147
    4. Norio Yamamoto
      Pages 149-156
    5. Takayuki Nakagawa, Satoyuki Kawano
      Pages 157-164
    6. Hiroshi Yamazaki
      Pages 165-177
  5. Hair Cell Regeneration

    1. Front Matter
      Pages 179-179
    2. Tomoko Kita
      Pages 181-188
    3. Akiko Taura, Takayuki Nakagawa
      Pages 189-197
    4. Norio Yamamoto
      Pages 199-207
    5. Koji Nishimura, Takayuki Nakagawa
      Pages 209-214
    6. Akiko Taura
      Pages 215-221
    7. Takayuki Okano
      Pages 223-234
  6. Spiral Ganglion Neuron Regeneration

    1. Front Matter
      Pages 235-235
    2. Harukazu Hiraumi
      Pages 237-245
    3. Koji Nishimura, Norio Yamamoto
      Pages 247-253
    4. Hiroshi Yamazaki, Takayuki Nakagawa
      Pages 255-264
    5. Tetsuji Sekiya, Masaaki Ishikawa
      Pages 265-272
    6. Takayuki Nakagawa
      Pages 273-277
  7. Stem Cells

    1. Front Matter
      Pages 279-279
    2. Mirei Taniguchi, Norio Yamamoto
      Pages 281-286
    3. Tatsunori Sakamoto, Koji Nishimura, Hiroe Ohnishi, Takehiro Iki
      Pages 287-303
    4. Takayuki Nakagawa
      Pages 305-310
  8. Future Perspective

    1. Front Matter
      Pages 311-311

About this book


The research described in this book represents important steps toward understanding the development of inner ear medicine and new perspectives in regenerative medicine, including efficacy in cochlear implants and various other treatments. The book depicts the mechanisms that underlie inner ear diseases, their experimental models, and proposals for new strategies to treat their symptoms. As well, the exciting future prospects for dealing with the very common problem of inner ear diseases are explained. These disorders occur among many people and include sensorineural hearing loss (SNHL), sudden deafness, senile deafness, noise-induced deafness, tinnitus, dizziness–vertigo, and Ménière’s disease. In Japan alone, there are more than 6 million deaf patients including those with middle-range deafness. There is currently no effective treatment, and regardless of the underlying cause, the damage has been considered irreversible. However, the results of recent research show that these patients actually can recover. The study of hair cells, spiral ganglion neurons, and stem cells for inner ear diseases such as SNHL, tinnitus, dizziness, and vertigo is at the forefront of regenerative medicine and may provide solutions to some of these problems. The information presented here makes this book a valuable professional reference work for all doctors and researchers in the field of otolaryngology who focus on regenerative treatments for inner ear diseases.


Cochlear Implant Hair Cell Inner Ear Regenerative Medicine Spiral Ganglion Neurons Stem Cell

Editors and affiliations

  • Juichi Ito
    • 1
  1. 1.Department of Otolaryngology-Head and Neck SurgeryKyoto University Graduate School of MedicineSakyo-kuJapan

Bibliographic information

  • DOI
  • Copyright Information Springer Japan 2014
  • Publisher Name Springer, Tokyo
  • eBook Packages Medicine
  • Print ISBN 978-4-431-54861-4
  • Online ISBN 978-4-431-54862-1
  • Buy this book on publisher's site