Carbon-Ion Radiotherapy

1. Front Matter

   Pages i-xii

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2. The History of Carbon-Ion Radiotherapy

   1. Front Matter

      Pages 1-1

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   2. History of Charged Particle Radiotherapy

      • Hirohiko Tsujii

      Pages 3-10

3. An Overview of Carbon-Ion Radiotherapy

   1. Front Matter

      Pages 11-11

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   2. The Characteristics of Carbon-Ion Radiotherapy

      • Tadashi Kamada

      Pages 13-16

   3. Overview of the Heavy-Ion Medical Accelerator in Chiba (HIMAC) Practices

      • Tadashi Kamada

      Pages 17-22

4. Radiobiology of Carbon-Ion Radiotherapy

   1. Front Matter

      Pages 23-23

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   2. Heavy-Ion Radiobiology

      • Yoshiya Furusawa

      Pages 25-37

   3. Biophysical Models and RBE

      • Naruhiro Matsufuji

      Pages 39-45

5. Carbon-Ion Radiotherapy System

   1. Front Matter

      Pages 47-47

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   2. Workflow of Carbon-Ion Radiotherapy

      • Toshiyuki Shirai, Yuka Takei

      Pages 49-52

   3. Beam-Delivery Systems

      • Shigekazu Fukuda, Takuji Furukawa, Yoshiyuki Iwata

      Pages 53-64

6. Oncology Information System

   1. Front Matter

      Pages 111-111

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   2. Oncology Information System

      • Yutaka Ando

      Pages 113-117

7. Evaluation of Treatment Outcome

   1. Front Matter

      Pages 119-119

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   2. Evaluation of Treatment Outcomes Using the Heavy-Ion Medical Accelerator in Chiba (HIMAC) Approach

      • Tadashi Kamada

      Pages 121-123

8. Head and Neck Tumors

   1. Front Matter

      Pages 125-125

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   2. Cancer of the Head and Neck

      • Azusa Hasegawa

      Pages 127-139

   3. Malignant Melanoma of the Head and Neck

      • Ryo Takagi

      Pages 141-147

   4. Soft Tissue Sarcoma of the Head and Neck

      • Masashi Koto

      Pages 149-152

This book serves as a practical guide for the use of carbon ions in cancer radiotherapy. On the basis of clinical experience with more than 7,000 patients with various types of tumors treated over a period of nearly 20 years at the National Institute of Radiological Sciences, step-by-step procedures and technological development of this modality are highlighted. The book is divided into two sections, the first covering the underlying principles of physics and biology, and the second section is a systematic review by tumor site, concentrating on the role of therapeutic techniques and the pitfalls in treatment planning. Readers will learn of the superior outcomes obtained with carbon-ion therapy for various types of tumors in terms of local control and toxicities. It is essential to understand that the carbon-ion beam is like a two-edged sword: unless it is used properly, it can increase the risk of severe injury to critical organs. In early series of dose-escalation studies, some patients experienced serious adverse effects such as skin ulcers, pneumonitis, intestinal ulcers, and bone necrosis, for which salvage surgery or hospitalization was required. To preclude such detrimental results, the adequacy of therapeutic techniques and dose fractionations was carefully examined in each case. In this way, significant improvements in treatment results have been achieved and major toxicities are no longer observed. With that knowledge, experts in relevant fields expand upon techniques for treatment delivery at each anatomical site, covering indications and optimal treatment planning. With its practical focus, this book will benefit radiation oncologists, medical physicists, medical dosimetrists, radiation therapists, and senior nurses whose work involves radiation therapy, as well as medical oncologists and others who are interested in radiation therapy.

• Cancer radiotherapy
• HIMAC
• Heavy ion
• Ion beams
• Protons
• Relative biological effectiveness
• Radiaton Oncology

• National Inst. of Radiological Sciences, Chiba, Japan

  Hirohiko Tsujii

• NIRS, Chiba, Japan

  Tadashi Kamada, Toshiyuki Shirai, Koji Noda, Hiroshi Tsuji, Kumiko Karasawa

Affiliation of all editors/authors: National Institute of Radiological Sciences