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About this book
This book guides the reader through the latest research on the cytokine network, covering signaling pathways, control of the immune response, and potential therapeutics. Different cytokines stimulate diverse responses in various phases of inflammation and immunity, including the innate immune response, the generation of effector T cells, and the development of antibodies by the humoral immune system. It is now clear that the pathophysiology of many infectious, autoimmune, allergic, and malignant diseases can be largely explained by which cytokines are induced and subsequently regulate the cellular responses. In clinical medicine, cytokines are involved in a wide spectrum of diseases. This book describes in three parts the properties and roles of 15 key cytokines under physiological and pathological conditions. Part I presents nine cytokines associated with inflammatory disorders, pro-inflammatory cytokines, and the recently identified new helper T (Th) subset: Th17 cells. Part II gives details of three cytokines associated with allergic disorders, including Th2 responses and recently identified types of innate cells. Part III describes three cytokines that are associated with immunological tolerance and anti-inflammation, including regulatory T (Treg) cells, IL-10-producing Treg (Tr1) cells, and inducible IL-35-producing Treg (iTr35) cells. Cytokines are considered to be important as therapeutic targets for specific agonists or antagonists in numerous immune and inflammatory diseases. The ultimate goal of this book is to facilitate the development of therapeutic treatments for such diseases which has been limited by an insufficient understanding of the biology of cytokines and the complicated network that they create.
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Keywords
Table of contents (15 chapters)
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Front Matter
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Cytokines in Inflammatory Disorders
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Front Matter
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Cytokines in Allergic Disorders
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Front Matter
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Cytokines in Immunological Tolerance and Anti-inflammation
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Front Matter
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Back Matter
Editors and Affiliations
Bibliographic Information
Book Title: Cytokine Frontiers
Book Subtitle: Regulation of Immune Responses in Health and Disease
Editors: Takayuki Yoshimoto, Tomohiro Yoshimoto
DOI: https://doi.org/10.1007/978-4-431-54442-5
Publisher: Springer Tokyo
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer Japan 2014
Hardcover ISBN: 978-4-431-54441-8Published: 12 November 2013
Softcover ISBN: 978-4-431-56124-8Published: 23 August 2016
eBook ISBN: 978-4-431-54442-5Published: 28 October 2013
Edition Number: 1
Number of Pages: XII, 396
Number of Illustrations: 44 illustrations in colour
Topics: Immunology, Cytokines and Growth Factors, Cell Biology