Serotonin and Sleep: Molecular, Functional and Clinical Aspects

  • Jaime M. Monti
  • S. R. Pandi-Perumal
  • Barry L. Jacobs
  • David J. Nutt

Table of contents

  1. Front Matter
    Pages I-XXVIII
  2. Evolution of concepts

  3. The dorsal raphe nucleus and median raphe nucleus: organization and projections

    1. Front Matter
      Pages 23-23
    2. Christopher A. Lowry, Andrew K. Evans, Paul J. Gasser, Matthew W. Hale, Daniel R. Staub, Anantha Shekhar
      Pages 25-67
  4. Serotonin receptors

    1. Front Matter
      Pages 133-133
    2. Noemí Santana, Julián de Almeida, Guadalupe Mengod, Francesc Artigas
      Pages 135-153
    3. Jason Hannon, Daniel Hoyer
      Pages 155-182
  5. Electrophysiology of serotonergic neurons and the regulation of serotonin release

    1. Front Matter
      Pages 183-183
    2. Barry L. Jacobs, Casimir A. Fornal
      Pages 185-204
    3. Pierre-Hervé Luppi, Damien Gervasoni, Christelle Peyron, Lucienne Leger, Denise Salvert, Patrice Fort
      Pages 237-250
  6. Serotonin receptors and the regulation of behavioural state

  7. Relevance of serotonin to clinical disorders and drug actions

    1. Front Matter
      Pages 527-527
    2. Spilios V. Argyropoulos, Sue J. Wilson, David J. Nutt
      Pages 569-585
  8. Back Matter
    Pages 611-621

About this book


Serotonin and Sleep: Molecular, Functional, and Clinical Aspects covers the complete spectrum of the field and explores the link between the latest basic molecular, functional, and clinical aspects of serotonin and the practice of sleep medicine. The volume focuses on 24 different areas of research, with special emphasis relating the state of basic and clinical research to potential applications: changing concepts in serotonin research, topographic organization and chemoarchitecture, receptor mechanisms – its organization and regulation of behavioral states, electrophysiological mechanisms – in vitro, in vivo, and behaving animals and other areas of molecular neurobiology. Also highlighted are studies related to the circadian control of behavioral states, and mechanisms involved in the serotonergic inhibition of REM sleep. Such discussion has profound implications for the basic biology of serotonin.

This unique volume not only explores the cutting-edge research, and the relationship of serotonin to laboratory animals as well as human sleep; it also explores the relevance of serotonin to clinical disorders such as depression, schizophrenia, and sleep apnea and brings these areas together to continue to promote the rapid expansion of knowledge in the area of serotonergic neurotransmission across behavioral states.

Written by an international cadre of researchers, this timely volume provides an up-to-date summary of what may be the only view on serotonin from the perspectives of neurobiologists, neuroanatomists, cell biologists, psychiatrists, neuropharmacologists, as well as sleep researchers.


Arousal Nervous System biology brain central nervous system cortex evolution molecular biology neurons physiology protein psychopharmacology receptor regulation serotonin

Editors and affiliations

  • Jaime M. Monti
    • 1
  • S. R. Pandi-Perumal
    • 2
  • Barry L. Jacobs
    • 3
  • David J. Nutt
    • 4
  1. 1.Pharmacology and Therapeutics, School of MedicineClinics HospitalMontevideoUruguay
  2. 2.Division of Clinical Pharmacology and Experimental Therapeutics, Department of MedicineCollege of Physicians and Surgeons of Columbia UniversityNew YorkUSA
  3. 3.Green Hall, Program in NeurosciencePrinceton UniversityPrincetonUSA
  4. 4.Psychopharmacology UnitBristolUK

Bibliographic information