Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

  • S. Elson
  • I. Howe
  • M. Jarman
  • P. G. McDougal
  • Judith Polonsky
  • N. R. Schmuff
  • R. Southgate
  • W. Herz
  • H. Grisebach
  • G. W. Kirby
  • Ch. Tamm

Table of contents

  1. Front Matter
    Pages I-VIII
  2. R. Southgate, S. Elson
    Pages 1-106
  3. P. G. McDougal, N. R. Schmuff
    Pages 153-219
  4. Judith Polonsky
    Pages 221-264
  5. Back Matter
    Pages 265-292

About this book

Introduction

More than ten years have elapsed since the publication of a compre­ hensive review on the quassinoids, the bitter principles of the Simaroubaceae family (80). Interest in these terpenoids has increased enormously in recent years due in part to the finding of the American National Cancer Institute in the early 1970s that these compounds display marked antileukemic activity. Furthermore, a wide spectrum of other biological properties for the quassinoids has been discovered and studies on chemical modifications of inactive members to yield biologically active ones were undertaken. New structures have been established also and numerous synthetic approaches have been developed which include the total synthesis of the parent compound, quassin (p. 250) and also that of castelanolide (p. 253). It is intended that this present chapter will be an extension of my first review in this series and will contain references up to September 1984. A short article on some aspects of this subject was published recently (81). II. Quassinoid General Features In reviewing the essential features of the quassinoids, the new structural types discovered during the last decade will be emphasised. The quassinoids can be divided into distinct groups according to their basic skeletons. The five skeletons observed are presented on Chart 1.

Keywords

chemistry natural product

Authors and affiliations

  • S. Elson
    • 1
  • I. Howe
    • 2
  • M. Jarman
    • 2
  • P. G. McDougal
    • 3
  • Judith Polonsky
    • 4
  • N. R. Schmuff
    • 5
  • R. Southgate
    • 1
  1. 1.Research DivisionBeecham PharmaceuticalsBetchworth, SurreyUK
  2. 2.Drug Metabolism Team, Section of Drug Development, Cancer Research Campaign LaboratoryInstitute of Cancer ResearchSutton, SurreyUK
  3. 3.Department of ChemistryGeorgia Institute of TechnologyAtlantaUSA
  4. 4.Institut de Chimie des Substances NaturellesC.N.R.S.Gif-sur-YvetteFrance
  5. 5.Questel, Inc.USA

Editors and affiliations

  • W. Herz
    • 1
  • H. Grisebach
    • 2
  • G. W. Kirby
    • 3
  • Ch. Tamm
    • 4
  1. 1.Department of ChemistryThe Florida State UniversityTallahasseeUSA
  2. 2.Biologisches Institut II, Lehrstuhl für Biochemie der PflanzenAlbert-Ludwigs-UniversitätFreiburg i. Br.Federal Republic of Germany
  3. 3.Chemistry DepartmentThe UniversityGlasgowScotland
  4. 4.Institut für Organische ChemieUniversität BaselBaselSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-7091-8790-6
  • Copyright Information Springer-Verlag Vienna 1985
  • Publisher Name Springer, Vienna
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-7091-8792-0
  • Online ISBN 978-3-7091-8790-6
  • Series Print ISSN 0071-7886
  • About this book