Advances in Stereotactic and Functional Neurosurgery 6

Proceedings of the 6th Meeting of the European Society for Stereotactic and Functional Neurosurgery, Rome 1983

  • Jan Gybels
  • Edward R. Hitchcock
  • Christoph Ostertag
  • Gian Franco Rossi
  • Jean Siegfried
  • Gabor Szikla

Part of the Acta Neurochirurgica book series (NEUROCHIRURGICA, volume 33)

Table of contents

  1. Front Matter
    Pages I-XIII
  2. Epilepsy

    1. Front Matter
      Pages 1-1
    2. Diagnosis

      1. J. Bancaud, A. Bonis, C. Munari, G. Szikla, J. P. Chodkiewicz, J. Talairach
        Pages 7-15
      2. C. Munari, A. Bonis, S. Kochen, M. Pestre, P. Brunet, J. Bancaud et al.
        Pages 47-52
      3. F. A. Lenz, R. R. Tasker, H. C. Kwan, J. T. Murphy, H. H. Nguyen-Huu
        Pages 57-61
      4. S. H. M. Nyström, P. H. Eskelinen, E. R. Heikkinen
        Pages 63-67
      5. G. F. Rossi, P. Pola, M. Scerrati
        Pages 69-73
      6. J. L. Barcia-Salorio, P. Roldán, S. Ramos, L. López Gómez, J. Broseta
        Pages 79-83
      7. G. B. Ricci, I. Modena, S. Barbanera, F. Campitelli, G. L. Romani
        Pages 85-89
      8. C. Munari, A. Bonis, J. Talairach, G. Szikla, J. P. Chodkiewicz, A. Musolino et al.
        Pages 91-96
      9. G. Broggi, A. Franzini, C. Giorgi, R. Spreafico, G. Avanzini
        Pages 97-103
      10. B. A. Meyerson, L. Widén, T. Greitz, G. Blomquist, E. Ehrin
        Pages 105-112
      11. P. Nádvorník, M. Lassanova, D. Homerova, T. Turský, M. Šramka
        Pages 113-118
      12. G. Rosadini, G. Rodriguez, W. G. Sannita, F. Arvigo
        Pages 119-122

About these proceedings

Introduction

Local interstitial radiation therapy of intrinsic and inaccessible brain tumors is confronted with two major problems: 1. The tolerance of normal brain tissue, which is usually involved in local tumor irradiation, i.e. perifocal white matter edema and demyelinating effects, is crucial. 2. Data on radiation effects of implanted radioactive sources on neoplastic tissue, i.e. data on the radiosensitivity and on the biology of tumors, are still widely unavailable. In clinical practice the dose with which to achieve a given volume of tumor necrosis is roughly estimated. This report deals with the experimental findings of Iodine-125 and Iridium-I92 permanent implants in healthy and neoplastic brain tissue. Our own experimental findings are correlated with experimental data on Yttnul11-l)O irradiation from the literature. The study is directed to collect data on the tolerance non-tumoral brain tissue and to attempt to establish a dose-response relationship. Morphologic Changes in the Dog Brain Following Interstitial Iodine-125 Irradiation Iodine-I25 seeds (manufactured by 3 M Company, St. Paul, M. N.) with an activity of 3.55 mCi were permanently implanted under stereotactic conditions into the subcortical white matter of the gyrus coronalis of the left hemisphere in 6 beagle dogs. One animal with a non-radioactive seed implanted under similar operative conditions served as a control. The animals were allowed to survive 25, 46, 71, 94, 248, 368 days, respectively, after the implantation. The control animal survived 46 days. A detailed description of the experimental procedure is given elsewhere 16. 17.

Keywords

Epilepsie Nervous System Tumor brachytherapy brainstem clinical application computed tomography (CT) diagnosis glioma neurosurgery positron emission tomography radiosurgery radiotherapy rehabilitation

Editors and affiliations

  • Jan Gybels
    • 1
  • Edward R. Hitchcock
    • 2
  • Christoph Ostertag
    • 3
  • Gian Franco Rossi
    • 4
  • Jean Siegfried
    • 5
  • Gabor Szikla
  1. 1.Department of NeurosurgeryAcademisch ZiekenhuisLeuvenBelgium
  2. 2.Midland Centre for Neurosurgery and NeurologyQueen Elizabeth HospitalBirminghamUK
  3. 3.Abteilung für StereotaxieNeurochirurgische UniversitätsklinikFreiburg i. Br.Germany
  4. 4.Istituto di NeurochirurgiaUniversità Cattolica del Sacro CuoreRomeItaly
  5. 5.Neurochirurgische KlinikUniversitätsspitalZürichSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-7091-8726-5
  • Copyright Information Springer-Verlag Vienna 1984
  • Publisher Name Springer, Vienna
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-211-81773-5
  • Online ISBN 978-3-7091-8726-5
  • Series Print ISSN 0065-1419
  • About this book