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Drug Receptor Interactions in Antimicrobial Chemotherapy

Symposium, Vienna, September 4–6, 1974

  • Jürgen Drews
  • E. Hahn
Conference proceedings

Part of the Topics in Infectious Diseases book series (TIDIS, volume 1)

Table of contents

  1. Front Matter
    Pages I-VIII
  2. Receptor Hypothesis

  3. DNA as a Drug-Receptor

    1. Front Matter
      Pages 57-57
    2. Royston Clowes, Toshihiko Arai, Gerry Anderson
      Pages 91-98
  4. Ribosomes as Drug-Receptors

    1. Front Matter
      Pages 115-115
    2. Georg Stöffler, Gilbert W. Tischendorf
      Pages 117-143
    3. Eric Cundliffe, Janet E. Beven, Peter D. Dixon
      Pages 167-177
    4. O. Pongs, R. Bald, V. A. Erdmann, E. Reinwald
      Pages 179-190
  5. The Mode of Action of Chloramphenicol

    1. Front Matter
      Pages 191-191
    2. D. Vazquez, M. Barbacid, R. Fernandez-Muñoz
      Pages 193-216
    3. R. Werner, A. Kollak, D. Nierhaus, G. Schreiner, K. H. Nierhaus
      Pages 217-234
    4. Fred E. Hahn, Peter Gund
      Pages 245-266
  6. Microbial Enzymes as Drug-Receptors

    1. Front Matter
      Pages 267-267
    2. L. S. Johnston, W. P. Hammes, H. A. Lazar, F. C. Neuhaus
      Pages 269-284
    3. J. J. Burchall
      Pages 285-293
    4. Guido R. Hartmann
      Pages 295-300
  7. Back Matter
    Pages 301-314

About these proceedings

Introduction

The concept of chemotherapy as originated by Paul Ehrlich is based on the premise that antiparasitic drugs must have two properties: they must first bind to specific structures of the parasite which Ehrlich called chemoreceptors. Subsequent to their attachment to the chemoreceptor and by virtue of this binding they must possess the capacity to kill the parasite. Since the host which is to be cured of an invading parasite also contains a large number of chemoreceptors, that have the potential to bind toxic compounds, the task of the chemo­ therapist is to identify chemoreceptors of the parasite which are . not represented in the host and to design drugs which bind selectively to them~ In this context, Ehrlich called· for "the complete and exhaustive knowledge of all the different chemoreceptors of a certain parasite" as a "sine qua non for success in chemotherapy". Paradoxically and in spite of the fact that chemotherapy has become a very advanced and successful therapeutic discipline, few of its tri­ umphs have been achieved by following Ehrlich's original precepts. On the contrary, in the overwhelming majority of cases, effective drugs have been discovered without any knowledge of their chemoreceptors, and these drugs themselves have conversely been used as tools to study the nature of the chemoreceptors involved. In other words: chemother­ apy, notably antibacterial chemotherapy, has been successful without ever living up to the fundamental standards put forward by Paul Ehr­ lich.

Keywords

Antimicrobial Chemotherapy Drug Interactions antimicrobial therapy

Editors and affiliations

  • Jürgen Drews
    • 1
  • E. Hahn
    • 2
  1. 1.Sandoz Forschungsinstitut Gesellschaft m. b. H.ViennaAustria
  2. 2.Walter Reed Army Medical CenterUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-7091-8405-9
  • Copyright Information Springer-Verlag Vienna 1975
  • Publisher Name Springer, Vienna
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-7091-8407-3
  • Online ISBN 978-3-7091-8405-9
  • Series Print ISSN 0171-2160
  • Buy this book on publisher's site