Hydrogen Sulfide and its Therapeutic Applications

1. Front Matter

   Pages i-ix

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2. Enzymology of Hydrogen Sulfide Turnover

   • Nicole Motl, Pramod Yadav, Ruma Banerjee

   Pages 1-35

3. Hydrogen Sulfide as an Oxygen Sensor

   • Kenneth R. Olson

   Pages 37-62

4. Multiple Roles of H2S in Inflammation: A New Class of Therapeutics?

   • Ling Li, Mohamed Shirhan Bin Mohamed, Philip K. Moore

   Pages 63-82

5. Signaling Mechanisms Underlying the Hydrogen Sulfide Effects: Identification of Hydrogen Sulfide “Receptors”

   • Yi-Chun Zhu

   Pages 83-107

6. Hydrogen Sulfide: Its Production, Release and Functions

   • Kyle L. Flannigan, John L. Wallace

   Pages 109-125

7. Hydrogen Sulfide: Physiological and Pathophysiological Functions

   • Yi Tong Liu, Jin-Song Bian

   Pages 127-156

8. Biological Effects of H2S Inhalation and Its Therapeutic Potential

   • Fumito Ichinose

   Pages 157-171

9. H2S as a Bacterial Defense Against Antibiotics

   • Lyly Luhachack, Evgeny Nudler

   Pages 173-180

10. Hydrogen Sulfide-Mediated Cellular Signaling and Cytoprotection

    • Hideo Kimura

    Pages 181-202

11. Back Matter

    Pages 203-207

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The metabolism of sulfur especially by sulfurtransferases had been intensively studied in mid 1900’s.  Three enzymes, cystathionine β–synthase (CBS), cystathionine γ–lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) were found to have the capacity to produce H₂S in vitro.  However, H₂S was recognized simply as a by-product of the metabolic pathways or as a marker for evaluating the activity of enzymes rather than as a physiological active molecule.   In the late 1980’s relatively high concentrations of sulfide were measured in the brain that led to the successive studies of identifying the physiological functions of H₂S.  Recently, the steady-state concentrations of H₂S have been re-evaluated and found to be much less than that initially measured.  However, despite these differences, such re-evaluations served to further confirm the existence of H₂S in mammalian tissues.  H₂S is produced in almost every organ and plays various roles such as neuromodulation, vasodilation, insulin release, inflammation, angiogenesis and cytoprotection. The unregulated production of H₂S and improper responses of target molecules are involved in the pathogenesis of various diseases.  This book focuses on these topics as well as on the recent progress in the biology and the therapeutic development of this molecule.

• inflammation
• neuromodulation
• sulfur metabolism
• sulfur transferase

• National Institut of Neuroscience, Tokyo, Japan

  Hideo Kimura

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