Basic Methods Handbook for Clinical Orthopaedic Research

A Practical Guide and Case Based Research Approach

  • Volker Musahl
  • Jón Karlsson
  • Michael T. Hirschmann
  • Olufemi R. Ayeni
  • Robert G. Marx
  • Jason L. Koh
  • Norimasa Nakamura

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Evidence Based Medicine in Orthopaedics

    1. Front Matter
      Pages 1-1
    2. Eleonor Svantesson, Eric Hamrin Senorski, Jón Karlsson, Olufemi R. Ayeni, Kristian Samuelsson
      Pages 3-10
    3. Vishal S. Desai, Christopher L. Camp, Aaron J. Krych
      Pages 11-22
    4. Naomi Roselaar, Magaly Iñiguez Cuadra, Stephen Lyman
      Pages 23-32
    5. Jason L. Koh, Diego Villacis
      Pages 33-42
    6. Michael Hantes, Apostolos Fyllos
      Pages 43-47
    7. Naomi Roselaar, Niv Marom, Robert G. Marx
      Pages 49-54
  3. How to Get Started with Clinical Research?

    1. Front Matter
      Pages 55-55
    2. Lachlan M. Batty, Timothy Lording, Eugene T. Ek
      Pages 57-63
    3. Lukas B. Moser, Michael T. Hirschmann
      Pages 65-73
    4. Karren Takamura, Frank Petrigliano
      Pages 75-81
    5. Yuichi Hoshino, Alfonso Barnechea
      Pages 83-88
    6. Monique C. Chambers, Sarah M. Tepe, Lorraine A. T. Boakye, MaCalus V. Hogan
      Pages 89-95
    7. José F. Vega, Kurt P. Spindler
      Pages 97-109
    8. Andrew Firth, Dianne Bryant, Jacques Menetrey, Alan Getgood
      Pages 111-120
    9. Caroline Mouton, Laura De Girolamo, Daniel Theisen, Romain Seil
      Pages 121-132
    10. Adam J. Popchak, Andrew D. Lynch, James J. Irrgang
      Pages 133-142
  4. Basics in Statistics: Statistics Made Simple!

    1. Front Matter
      Pages 151-151
    2. Stephan Bodkin, Joe Hart, Brian C. Werner
      Pages 153-161
    3. Clair Smith
      Pages 163-170
    4. Carola F. van Eck, Marcio Bottene Villa Albers, Andrew J. Sheean, Freddie H. Fu
      Pages 171-183
    5. Stephen Lyman
      Pages 185-191
    6. Stephen Lyman, Naomi Roselaar, Chisa Hidaka
      Pages 193-206
  5. Basic Toolbox for the Young Clinical Researcher

    1. Front Matter
      Pages 207-207
    2. Elmar Herbst, Brian Forsythe, Avinesh Agarwalla, Sebastian Kopf
      Pages 209-217
    3. Baris Kocaoglu, Paulo Henrique Araujo, Carola Francisca van Eck
      Pages 219-225
    4. Timothy Lording, Jacques Menetrey
      Pages 227-233
    5. Brendan Coleman
      Pages 235-242
    6. Thomas R. Pfeiffer, Daniel Guenther
      Pages 243-247
    7. Christian Lattermann, Janey D. Whalen
      Pages 249-254
    8. Neel K. Patel, Marco Yeung, Kanto Nagai, Volker Musahl
      Pages 255-262
  6. How to Perform a Clinical Study: A Case Based Approach

    1. Front Matter
      Pages 263-263
    2. Seper Ekhtiari, Raman Mundi, Vickas Khanna, Mohit Bhandari
      Pages 265-283
    3. Daisuke Araki, Ryosuke Kuroda
      Pages 285-287
    4. Naomi Roselaar, Niv Marom, Robert G. Marx
      Pages 289-293
    5. Andrew D. Lynch, Adam J. Popchak, James J. Irrgang
      Pages 295-300
    6. Mitchell I. Kennedy, Robert F. LaPrade
      Pages 301-305
    7. Andrew J. Sheean, Gregory V. Gasbarro, Nasef M. N. Abedelatif, Volker Musahl
      Pages 307-312
    8. Seán Mc Auliffe, Pieter D’Hooghe
      Pages 313-319
  7. How to Perform a Review Article?

    1. Front Matter
      Pages 321-321
    2. Matthew Skelly, Andrew Duong, Nicole Simunovic, Olufemi R. Ayeni
      Pages 323-327
  8. How to Perform a Systematic Review or Meta-analysis?

    1. Front Matter
      Pages 329-329
    2. Shakib Akhter, Thierry Pauyo, Moin Khan
      Pages 331-342
    3. Kelsey L. Wise, Brandon J. Kelly, Michael L. Knudsen, Jeffrey A. Macalena
      Pages 343-358
    4. R. Kyle Martin, Andreas Persson, Håvard Visnes, Lars Engebretsen
      Pages 359-369
  9. How to Perform an Economic Health Care Study?

    1. Front Matter
      Pages 371-371
    2. Jonathan Edgington, Xander Kerman, Lewis Shi, Jason L. Koh
      Pages 373-380
  10. Multi-Center Study: How to Pull It Off?

    1. Front Matter
      Pages 381-381

About this book


This book is designed to meet the needs of both novice and senior researchers in Orthopaedics by providing the essential, clinically relevant knowledge on research methodology that is sometimes overlooked during training. Readers will find a wealth of easy-to-understand information on all relevant aspects, from protocol design, the fundamentals of statistics, and the use of computer-based tools through to the performance of clinical studies with different levels of evidence, multicenter studies, systematic reviews, meta-analyses, and economic health care studies. A key feature is a series of typical case examples that will facilitate use of the volume as a handbook for most common research approaches and study types. Younger researchers will also appreciate the guidance on preparation of abstracts, poster and paper presentations, grant applications, and publications. The authors are internationally renowned orthopaedic surgeons with extensive research experience and the book is published in collaboration with ISAKOS.


Manuscript writing Clinical research practice Study Scientific meeting Scientific article Research methodology

Editors and affiliations

  • Volker Musahl
    • 1
  • Jón Karlsson
    • 2
  • Michael T. Hirschmann
    • 3
  • Olufemi R. Ayeni
    • 4
  • Robert G. Marx
    • 5
  • Jason L. Koh
    • 6
  • Norimasa Nakamura
    • 7
  1. 1.UPMC Rooney Sports ComplexUniversity of PittsburghPittsburghUSA
  2. 2.Department of Orthopaedics, Sahlgrenska AcademyGothenburg University, Sahlgrenska University HospitalGothenburgSweden
  3. 3.Department of Orthopaedic Surgery and TraumatologyKantonsspital Baselland (Bruderholz, Laufen und Liestal)BruderholzSwitzerland
  4. 4.McMaster UniversityHamiltonCanada
  5. 5.Hospital for Special SurgeryNew YorkUSA
  6. 6.Department of Orthopaedic SurgeryNorthShore University HealthSystemEvanstonUSA
  7. 7.Institute for Medical Science in SportsOsaka Health Science UniversityOsakaJapan

Bibliographic information