Overview
- Nominated by the Chinese University of Hong Kong as an outstanding Ph.D. thesis
- Systematically elucidates a self-developed labeling method of covalent protein conjugation
- Reports a novel anti-fungus peptide drug design and revolution
- Introduces the secondary-structure-based binding effects of proteins on quantum dots
- Includes supplementary material: sn.pub/extras
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (6 chapters)
Keywords
About this book
This thesis focuses on the study of interactions between protein and peptides and their potential applications in cell imaging and nanoparticle surface modification. Drawing inspiration from naturally occurring coiled-coil binding pairs, it proposes a novel covalent peptide tag and probe system, based on the concept of “affinity guided covalent conjugation.” This newly established methodology provides complementary resolution to protein labeling, imaging and trafficking. By systematically investigating the coordination interaction between protein and quantum dots using various engineered protein ligands, this thesis proposes a general rule for protein self-assembly on the surface of quantum dots and reports a revolutionized nanobelt protein in accordance with this rule. It is an extraordinary example of interdisciplinary research, providing answers to real-life biological problems from a chemistry perspective.
Authors and Affiliations
Bibliographic Information
Book Title: Study of the Peptide-Peptide and Peptide-Protein Interactions and Their Applications in Cell Imaging and Nanoparticle Surface Modification
Authors: Jianpeng Wang
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-3-662-53399-4
Publisher: Springer Berlin, Heidelberg
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer-Verlag Berlin Heidelberg 2016
Hardcover ISBN: 978-3-662-53397-0Published: 05 October 2016
Softcover ISBN: 978-3-662-57134-7Published: 15 June 2018
eBook ISBN: 978-3-662-53399-4Published: 26 September 2016
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XIII, 96
Number of Illustrations: 5 b/w illustrations, 41 illustrations in colour
Topics: Biotechnology, Protein Science, Nanotechnology, Bioorganic Chemistry