Pain Control

  • Hans-Georg┬áSchaible

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 227)

Table of contents

  1. Front Matter
    Pages i-viii
  2. Ram Kandasamy, Theodore J. Price
    Pages 15-37
  3. Abdella M. Habib, John N. Wood, James J. Cox
    Pages 39-56
  4. Kazue Mizumura, Shiori Murase
    Pages 57-77
  5. Stephen G. Woodhams, Devi Rani Sagar, James J. Burston, Victoria Chapman
    Pages 119-143
  6. Elizabeth Amy Old, Anna K. Clark, Marzia Malcangio
    Pages 145-170
  7. Andrew J. Todd
    Pages 171-190
  8. Jacob Thomas, Sanam Mustafa, Jacinta Johnson, Lauren Nicotra, Mark Hutchinson
    Pages 207-238
  9. Jason J. McDougall, Milind M. Muley
    Pages 239-260
  10. Volker Neugebauer
    Pages 261-284
  11. Martin Schmelz
    Pages 285-301
  12. Back Matter
    Pages 303-309

About this book


This volume addresses neuronal pain mechanisms at the peripheral, spinal and supraspinal level which are thought to significantly contribute to pain and which may be the basis for the development of new treatment principles. Chapters on nociceptive mechanisms in the peripheral nociceptive system address the concept of hyperalgesic priming, the role of voltage-gated sodium channels in different inflammatory and neuropathic pain states, the hyperalgesic effects of NGF in different tissues and in inflammatory and neuropathic pain states, and the contribution of proteinase activated receptors (PAR) to the development of pain in several chronic pain conditions. Chapters on nociceptive mechanisms in the spinal cord address the particular role of NO and of glial cell activation in the generation and maintenance of inflammatory and neuropathic pain and it discusses the potential role of local inhibitory interneurons, of the endogenous endocannabinoid system and the importance of non-neuronal immune mechanisms in opioid signaling in the control of pain. Furthermore, it is presented how spinal mechanisms contribute to the expression of peripheral inflammation.


calcium channels drug therapy pain control pain mechanisms sodium channels spinal cord

Editors and affiliations

  • Hans-Georg┬áSchaible
    • 1
  1. 1.Institute of Physiology/NeurophysiologyJena University HospitalJenaGermany

Bibliographic information