Cancer Immunology

1. Front Matter

   Pages i-l

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2. Frontiers in Cancer Immunotherapy

   • Joseph F. Murphy

   Pages 1-22

3. Novel Strategy of Cancer Immunotherapy: Spiraling Up

   • Lev V. Demidov, Irina Zh. Shubina, Mikhail V. Kiselevsky

   Pages 23-33

4. Novel Prognostic Biomarkers for Personalized Cancer Treatment

   • Ida Contasta, Anna Maria Berghella, Roberto Lattanzio, Osvaldo Ciccarelli, Giancarlo Di Gregorio, Maurizio Vizioli et al.

   Pages 35-54

5. Tumor Antigen and Epitope Identification for Preclinical and Clinical Evaluation

   • Shraddha S. Rane, Jaimy Mariam Sultana Javad, Robert C. Rees

   Pages 55-71

6. Strategies to Target Tumor Immunosuppression

   • Oana Draghiciu, Hans W. Nijman, Toos Daemen

   Pages 73-86

7. Overcoming Cancer Tolerance with Immune Checkpoint Blockade

   • Guy T. Clifton, Elizabeth A. Mittendorf, George E. Peoples

   Pages 87-129

8. Gene Therapy and Virus-Based Cancer Vaccines

   • Mohamed Labib Salem, Kamal Kamal Elsayed Gadalla, Burtram C. Fielding, Steve H. Thorne

   Pages 131-150

9. Cancer Stem Cells: Biology and Potential Therapeutic Applications

   • Monica Mangoni, Mariangela Sottili, Mauro Loi, Chiara Gerini, Icro Meattini, Lorenzo Livi

   Pages 151-176

10. Immunologic Approaches to Targeting Cancer Stem Cells

    • Qin Pan, Qiao Li, Ning Ning, Yingxin Xu, Alfred E. Chang, Max S. Wicha

    Pages 177-188

11. Hematopoietic Stem Cell Transplantation and Lymphodepletion for the Treatment of Cancer

    • Kristen M. Barr, Jill A. Gershan, Bryon D. Johnson

    Pages 189-201

12. Combination of Chemotherapy and Cytokine Therapy in Treatment of Cancers

    • Mariana Malvicini, Manglio M. Rizzo, Laura Alaniz, Guillermo D. Mazzolini

    Pages 203-215

13. T Cell Immunotherapy: From Synthetic Biology to Clinical Practice

    • Ling Zhang, Rimas J. Orentas

    Pages 217-230

14. Role of γδ T Lymphocytes in Cancer Immunosurveillance and Immunotherapy

    • Telma Lança, Daniel V. Correia, Bruno Silva-Santos

    Pages 231-262

15. Adoptive T-Cell Therapy: Optimizing Chemokine Receptor-Mediated Homing of T Cells in Cancer Immunotherapy

    • Imran Siddiqui, Alberto Mantovani, Paola Allavena

    Pages 263-282

16. B Cell Regulation of Antitumor Response

    • Ahmed Al Bayati, Yu Zhang, Joseph D. Rosenblatt

    Pages 283-292

17. Monoclonal Antibodies for Cancer Immunotherapy

    • Amir-Hassan Zarnani, Mahmood Bozorgmehr, Mahdi Shabani, Leila Barzegar-Yarmohammadi, Fatemeh Ghaemimanesh, Mahmood Jeddi-Tehrani

    Pages 293-328

18. Toll-Like Receptor Pathway and its Targeting in Treatment of Cancers

    • Seyed Hossein Aalaei-Andabili, Shaherin Basith, Sangdun Choi, Nima Rezaei

    Pages 329-339

19. Recent Advances in the Use of NK Cells Against Cancer

    • Amy E. Gillgrass, Tamara Krneta, Ali A. Ashkar

    Pages 341-358

20. Dendritic Cell Vaccines for Cancer Therapy: Fundamentals and Clinical Trials

    • Graziela Gorete Romagnoli, Ramon Kaneno

    Pages 359-373

This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. The scope is broad, encompassing, for example, prognostic biomarkers for personalized cancer treatment, strategies for targeting tumor immunosuppression, gene therapy, virus-based vaccines, targeting of cancer stem cells, hematopoietic stem cell transplantation, the role of T lymphocytes in cancer immunotherapy, use of monoclonal antibodies, and many more innovative approaches. Clinical immunologists, hematologists, and oncologists in particular will find the book to be of value in expanding their knowledge. The book is the second in a three-volume series, Cancer Immunology, which offers an up-to-date review of cancer immunology and immunotherapy. The remaining volumes focus on the immunopathology of cancers and cancer immunotherapy for organ-specific tumors. In total the series, designed for both clinicians and researchers, includes contributions from more than 250 scientists working at leading universities and institutes from across the world.

• Cancer immunology
• Cancer immunotherapy
• Cancer stem cells
• Radioimmunotherapy
• Translational medicine

• Research Center for Immunodeficiencies, Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran

  Nima Rezaei

Nima Rezaei gained his medical degree from Tehran University of Medical Sciences and Health Services in 2002 and subsequently obtained MSc in Molecular and Genetic Medicine and PhD in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also spent a short-term fellowship of Clinical Immunology and Bone Marrow Transplantation in the Newcastle General Hospital. Since 2010, Dr. Rezaei has worked at the Department of Immunology, School of Medicine, Tehran University of Medical Sciences; he is also the Chief Executive Director of the Children’s Medical Center Hospital, Tehran and a co-founder and Deputy President of the Research Center for Immunodeficiencies. In addition, Dr. Rezaei is an Honorary Research Fellow at the Department of Infection and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield. Dr. Rezaei has already been the Director of more than 50 research projects and has designed and participated in several international collaborative projects. Dr. Rezaei is an editorial assistant or board member for more than 20 international journals. He has published more than 400 articles in international scientific journals and edited ten further books.