Skip to main content
  • Book
  • © 2015

Cancer Immunology

Bench to Bedside Immunotherapy of Cancers

  • Offers an up-to-date review of cancer immunology in animal models and human cancers

  • Provides a bench to bedside approach to the immunology of cancers, with a focus on clinical aspects

  • Describes in depth the interactions between cancerous cells and various components of the innate and adaptive immune system

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-3-662-44946-2
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 139.99
Price excludes VAT (USA)

This is a preview of subscription content, access via your institution.

Table of contents (27 chapters)

  1. Front Matter

    Pages i-l
  2. Frontiers in Cancer Immunotherapy

    • Joseph F. Murphy
    Pages 1-22
  3. Novel Strategy of Cancer Immunotherapy: Spiraling Up

    • Lev V. Demidov, Irina Zh. Shubina, Mikhail V. Kiselevsky
    Pages 23-33
  4. Novel Prognostic Biomarkers for Personalized Cancer Treatment

    • Ida Contasta, Anna Maria Berghella, Roberto Lattanzio, Osvaldo Ciccarelli, Giancarlo Di Gregorio, Maurizio Vizioli et al.
    Pages 35-54
  5. Tumor Antigen and Epitope Identification for Preclinical and Clinical Evaluation

    • Shraddha S. Rane, Jaimy Mariam Sultana Javad, Robert C. Rees
    Pages 55-71
  6. Strategies to Target Tumor Immunosuppression

    • Oana Draghiciu, Hans W. Nijman, Toos Daemen
    Pages 73-86
  7. Overcoming Cancer Tolerance with Immune Checkpoint Blockade

    • Guy T. Clifton, Elizabeth A. Mittendorf, George E. Peoples
    Pages 87-129
  8. Gene Therapy and Virus-Based Cancer Vaccines

    • Mohamed Labib Salem, Kamal Kamal Elsayed Gadalla, Burtram C. Fielding, Steve H. Thorne
    Pages 131-150
  9. Cancer Stem Cells: Biology and Potential Therapeutic Applications

    • Monica Mangoni, Mariangela Sottili, Mauro Loi, Chiara Gerini, Icro Meattini, Lorenzo Livi
    Pages 151-176
  10. Immunologic Approaches to Targeting Cancer Stem Cells

    • Qin Pan, Qiao Li, Ning Ning, Yingxin Xu, Alfred E. Chang, Max S. Wicha
    Pages 177-188
  11. Hematopoietic Stem Cell Transplantation and Lymphodepletion for the Treatment of Cancer

    • Kristen M. Barr, Jill A. Gershan, Bryon D. Johnson
    Pages 189-201
  12. Combination of Chemotherapy and Cytokine Therapy in Treatment of Cancers

    • Mariana Malvicini, Manglio M. Rizzo, Laura Alaniz, Guillermo D. Mazzolini
    Pages 203-215
  13. T Cell Immunotherapy: From Synthetic Biology to Clinical Practice

    • Ling Zhang, Rimas J. Orentas
    Pages 217-230
  14. Role of γδ T Lymphocytes in Cancer Immunosurveillance and Immunotherapy

    • Telma Lança, Daniel V. Correia, Bruno Silva-Santos
    Pages 231-262
  15. B Cell Regulation of Antitumor Response

    • Ahmed Al Bayati, Yu Zhang, Joseph D. Rosenblatt
    Pages 283-292
  16. Monoclonal Antibodies for Cancer Immunotherapy

    • Amir-Hassan Zarnani, Mahmood Bozorgmehr, Mahdi Shabani, Leila Barzegar-Yarmohammadi, Fatemeh Ghaemimanesh, Mahmood Jeddi-Tehrani
    Pages 293-328
  17. Toll-Like Receptor Pathway and its Targeting in Treatment of Cancers

    • Seyed Hossein Aalaei-Andabili, Shaherin Basith, Sangdun Choi, Nima Rezaei
    Pages 329-339
  18. Recent Advances in the Use of NK Cells Against Cancer

    • Amy E. Gillgrass, Tamara Krneta, Ali A. Ashkar
    Pages 341-358
  19. Dendritic Cell Vaccines for Cancer Therapy: Fundamentals and Clinical Trials

    • Graziela Gorete Romagnoli, Ramon Kaneno
    Pages 359-373

About this book

This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. The scope is broad, encompassing, for example, prognostic biomarkers for personalized cancer treatment, strategies for targeting tumor immunosuppression, gene therapy, virus-based vaccines, targeting of cancer stem cells, hematopoietic stem cell transplantation, the role of T lymphocytes in cancer immunotherapy, use of monoclonal antibodies, and many more innovative approaches. Clinical immunologists, hematologists, and oncologists in particular will find the book to be of value in expanding their knowledge. The book is the second in a three-volume series, Cancer Immunology, which offers an up-to-date review of cancer immunology and immunotherapy. The remaining volumes focus on the immunopathology of cancers and cancer immunotherapy for organ-specific tumors. In total the series, designed for both clinicians and researchers, includes contributions from more than 250 scientists working at leading universities and institutes from across the world.


  • Cancer immunology
  • Cancer immunotherapy
  • Cancer stem cells
  • Radioimmunotherapy
  • Translational medicine

Editors and Affiliations

  • Research Center for Immunodeficiencies, Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

About the editor

Nima Rezaei gained his medical degree from Tehran University of Medical Sciences and Health Services in 2002 and subsequently obtained MSc in Molecular and Genetic Medicine and PhD in Clinical Immunology and Human Genetics from the University of Sheffield, UK. He also spent a short-term fellowship of Clinical Immunology and Bone Marrow Transplantation in the Newcastle General Hospital. Since 2010, Dr. Rezaei has worked at the Department of Immunology, School of Medicine, Tehran University of Medical Sciences; he is also the Chief Executive Director of the Children’s Medical Center Hospital, Tehran and a co-founder and Deputy President of the Research Center for Immunodeficiencies. In addition, Dr. Rezaei is an Honorary Research Fellow at the Department of Infection and Immunity, School of Medicine and Biomedical Sciences, University of Sheffield. Dr. Rezaei has already been the Director of more than 50 research projects and has designed and participated in several international collaborative projects. Dr. Rezaei is an editorial assistant or board member for more than 20 international journals. He has published more than 400 articles in international scientific journals and edited ten further books.

Bibliographic Information

  • Book Title: Cancer Immunology

  • Book Subtitle: Bench to Bedside Immunotherapy of Cancers

  • Editors: Nima Rezaei

  • DOI:

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2015

  • Softcover ISBN: 978-3-662-51383-5Published: 06 October 2016

  • eBook ISBN: 978-3-662-44946-2Published: 29 December 2015

  • Edition Number: 1

  • Number of Pages: L, 485

  • Number of Illustrations: 7 b/w illustrations, 38 illustrations in colour

  • Topics: Internal Medicine, Immunology, Oncology

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • ISBN: 978-3-662-44946-2
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 139.99
Price excludes VAT (USA)