Monoclonal Antibodies in Transplantation

1. Front Matter

   Pages N2-xi

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2. Clinical Uses of Polyclonal and Monoclonal Antilymphoid Sera

   • Mary Ann Simpson, Anthony P. Monaco

   Pages 1-19

3. The Experimental and Clinical Use in Transplantation of Monoclonal Antibodies to CD4 and Other Adhesion Molecules

   • John Powelson, A. Benedict Cosimi

   Pages 21-52

4. The Clinical and Experimental Use of Monoclonal Antibodies to the IL-2 Receptor

   • Peter L. Amlot

   Pages 53-98

5. The Use of OKT3 in Clinical Transplantation

   • Daniel Abramowicz, Michel Goldman

   Pages 99-135

6. Monoclonal Antibodies to Adhesion Molecules in Bone Marrow and Organ Transplantation

   • Alain Fischer, M. Cavazzana-Calvo, N. Jabado, S. Sarnacki

   Pages 137-153

7. Future Goals for Therapeutic Monoclonal Antibodies

   • Lucienne Chatenoud, Michelle Webb, Jean-François Bach

   Pages 155-182

8. Back Matter

   Pages 183-190

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Experimental and clinical evidence presented in this book illustrates that antibodies expressing different specificities can be very effective in preventing or reversing established transplant rejection. Moreover, the data leads us to hope that the use of these new therapeutic agents may allow the induction of specific tolerance to transplant alloantigens which is the only means to avoid the major risks of sustained immunosuppression, namely an increased susceptibility to infection and tumor development. In this volume the editors combine contributions dealing with very practical aspects of the clinical use of monoclonal antibodies with a more general discussion on the developments one may foresee in the near future.

• Antigen
• ICAM1
• adhesion
• allograft
• bone marrow transplantation
• cyctokines
• immunological tolerance
• immunosuppression
• immunotherapy
• infection
• molecules
• rejection
• transplantation

• INSERM U25, Hôpital Necker, Paris, France

  Lucienne Chatenoud

Policies and ethics