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  • © 2000

Clostridium difficile

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Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 250)

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  • ISBN: 978-3-662-06272-2
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Table of contents (7 chapters)

  1. Front Matter

    Pages i-ix
  2. Genetics of Clostridium difficile Toxins

    • J. S. Moncrief, T. D. Wilkins
    Pages 35-54
  3. Molecular Mode of Action of the Large Clostridial Cytotoxins

    • I. Just, F. Hofmann, K. Aktories
    Pages 55-83
  4. Cytotoxic Effects of the Clostridium difficile Toxins

    • M. Thelestam, E. Chaves-Olarte
    Pages 85-96
  5. Back Matter

    Pages 141-146

About this book

Clostridium difficile has been recognized as the cause of a broad spectrum of enteric disease ranging from mild antibiotic-associated diarrhea to pseudomembranous colitis. This volume gives new insights into the microbiology, diagnostics and epidemiology of Clostridium difficile and describes recent strategies in treatment of diseases caused by this agent. Main parts of the volume are devoted to Clostridium difficile toxins A and B which are the major virulence factors. The molecular biology, biochemistry, pharmacology and cell biology of these toxins which are the prototypes of a new family of large clostridial cytotoxins is described in great detail. Clostridium difficile toxins act as glucosyltransferases to inactivate small GTP-binding proteins of the Rho family which are involved in regulation of the actin cytoskeleton, cell adhesion and various signaling processes.

Keywords

  • biochemistry
  • biology
  • cell
  • cell biology
  • genetics
  • infection
  • microbiology
  • molecular biology
  • pathogenesis
  • pharmacology
  • protein
  • proteins
  • regulation
  • toxin
  • virulence

Editors and Affiliations

  • Institut für Pharmakologie und Toxikologie, Albert-Ludwigs-Universität Freiburg, Freiburg i. Br., Germany

    Klaus Aktories

  • Virginia Tech, Fralin Biotechnology Center, Blacksburg, USA

    Tracy D. Wilkins

Bibliographic Information

Buying options

eBook
USD 149.00
Price excludes VAT (USA)
  • ISBN: 978-3-662-06272-2
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book
USD 199.99
Price excludes VAT (USA)
Hardcover Book
USD 219.99
Price excludes VAT (USA)