Clostridium difficile

  • Klaus Aktories
  • Tracy D. Wilkins

Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 250)

Table of contents

  1. Front Matter
    Pages i-ix
  2. J. S. Moncrief, T. D. Wilkins
    Pages 35-54
  3. I. Just, F. Hofmann, K. Aktories
    Pages 55-83
  4. M. Thelestam, E. Chaves-Olarte
    Pages 85-96
  5. Back Matter
    Pages 141-146

About this book


Clostridium difficile has been recognized as the cause of a broad spectrum of enteric disease ranging from mild antibiotic-associated diarrhea to pseudomembranous colitis. This volume gives new insights into the microbiology, diagnostics and epidemiology of Clostridium difficile and describes recent strategies in treatment of diseases caused by this agent. Main parts of the volume are devoted to Clostridium difficile toxins A and B which are the major virulence factors. The molecular biology, biochemistry, pharmacology and cell biology of these toxins which are the prototypes of a new family of large clostridial cytotoxins is described in great detail. Clostridium difficile toxins act as glucosyltransferases to inactivate small GTP-binding proteins of the Rho family which are involved in regulation of the actin cytoskeleton, cell adhesion and various signaling processes.


biochemistry biology cell cell biology genetics infection microbiology molecular biology pathogenesis pharmacology protein proteins regulation toxin virulence

Editors and affiliations

  • Klaus Aktories
    • 1
  • Tracy D. Wilkins
    • 2
  1. 1.Institut für Pharmakologie und ToxikologieAlbert-Ludwigs-Universität FreiburgFreiburg i. Br.Germany
  2. 2.Virginia TechFralin Biotechnology CenterBlacksburgUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2000
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-08668-7
  • Online ISBN 978-3-662-06272-2
  • Series Print ISSN 0070-217X
  • Buy this book on publisher's site