Pharmacokinetic Challenges in Drug Discovery

  • O. Pelkonen
  • A. Baumann
  • A. Reichel

Part of the Ernst Schering Research Foundation Workshop book series (SCHERING FOUND, volume 37)

Table of contents

  1. Front Matter
    Pages I-XIV
  2. A. M. Davis, J. Dixon, C. J. Logan, D. W. Payling
    Pages 1-32
  3. G. S. J. Mannens, H. Bohets, P. Verboven, K. Steemans, K. Lavrijsen, W. Meuldermans
    Pages 49-67
  4. M. K. Bayliss, P. J. Eddershaw
    Pages 69-79
  5. T. Lavé, O. Luttringer, J. Zuegge, G. Schneider, P. Coassolo, F.-P. Theil
    Pages 81-104
  6. O. Pelkonen, J. Hukkanen, P. Honkakoski, J. Hakkola, P. Viitala, H. Raunio
    Pages 105-137
  7. Andreas Baumann, Martin Bayliss, Thorsten Blume, Ulf Boemer, Gerardine Burton, Gabriele Cruziani et al.
    Pages 249-298
  8. Back Matter
    Pages 299-306

About these proceedings


Despite increased spending on research and development, the number of new medicines marketed successfully continues to decline. The Pharmaceutical industry is therefore focussing on ways to reduce attrition by addressing frequent reasons for clinical drug failures very early in the drug discovery process. One of the biggest challenges is the pharmacokinetic (PK) optimisation of drug candidates tailored and predicted to have appropriate absorption, distribution, metabolism and excretion (ADME) characteristics in human. This book describes how traditional pbarmacokinetic approaches and methods are being re-invented' to meet specific needs dictated by the dynamics of the drug discovery process. The book gives an overview of state-of-the-art tools and their use in the decision-making process is discussed by a number of scientists from leading pharmaceutical companies.


Drug Metabolism Pharmocokinetics absorption cytochrome P450 drug drug development drug discovery drug research kinetics metabolism pharmacokinetics research

Editors and affiliations

  • O. Pelkonen
    • 1
  • A. Baumann
    • 2
  • A. Reichel
    • 2
  1. 1.Department of Pharmacology and ToxicologyUniversity of OuluOuluFinnland
  2. 2.Research PharmacokineticsSchering AGBerlinGermany

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2002
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-662-04385-1
  • Online ISBN 978-3-662-04383-7
  • Series Print ISSN 0947-6075
  • Buy this book on publisher's site