Human Genetics

Problems and Approaches

  • Friedrich Vogel
  • Arno G. Motulsky

Table of contents

  1. Front Matter
    Pages I-XXXVI
  2. Friedrich Vogel, Arno G. Motulsky
    Pages 1-9
  3. Friedrich Vogel, Arno G. Motulsky
    Pages 11-23
  4. Friedrich Vogel, Arno G. Motulsky
    Pages 25-82
  5. Friedrich Vogel, Arno G. Motulsky
    Pages 83-127
  6. Friedrich Vogel, Arno G. Motulsky
    Pages 129-162
  7. Friedrich Vogel, Arno G. Motulsky
    Pages 163-193
  8. Friedrich Vogel, Arno G. Motulsky
    Pages 195-256
  9. Friedrich Vogel, Arno G. Motulsky
    Pages 257-360
  10. Friedrich Vogel, Arno G. Motulsky
    Pages 361-383
  11. Friedrich Vogel, Arno G. Motulsky
    Pages 385-430
  12. Friedrich Vogel, Arno G. Motulsky
    Pages 431-456
  13. Friedrich Vogel, Arno G. Motulsky
    Pages 457-493
  14. Friedrich Vogel, Arno G. Motulsky
    Pages 495-548
  15. Friedrich Vogel, Arno G. Motulsky
    Pages 549-582
  16. Friedrich Vogel, Arno G. Motulsky
    Pages 583-621
  17. Friedrich Vogel, Arno G. Motulsky
    Pages 623-691
  18. Friedrich Vogel, Arno G. Motulsky
    Pages 693-704
  19. Friedrich Vogel, Arno G. Motulsky
    Pages 705-710
  20. Friedrich Vogel, Arno G. Motulsky
    Pages 711-732

About this book

Introduction

The first two editions of this book, published in 1979 and in 1986, were well re­ ceived by the scientific community. Translations into Italian, Japanese, and Rus­ sian suggest that this book was regarded useful in many parts of the world. Mean­ while, human genetics has seen dramatic developments, and the "molecular revo­ lution" has attracted thousands of scientists, including many molecular biologists, to this field. About 3700 human genes have already been mapped to chromosomal sites. Many such genes have been cloned, and the various mutations causing dis­ ease have been identified. Novel mutational mechanisms such as expanded trinu­ cleotide repeats have been discovered in conditions such as Huntington's disease and the fragile X syndrome of mental retardation. Gene action now can often be elucidated by studying the pathway from gene to phenotype following positional cloning rather than working in the opposite direction, as was customarily done be­ fore the tools of "new genetics" were available. In an increasing number of genetic diseases, the pathogenic mechanisms have been elucidated with positive conse­ quences for prevention and treatment. It therefore became necessary to rewrite al­ most completely major portions of this book. These developments are now making genetics arguably the leading basic science for medicine, as well as a recognized medical speciality. But all these changes do not mean that the entire framework of human genetics had to be reconstructed.

Keywords

Evolution Genetic Analysis Heredity Human development Inborn Diseases Mutation Proteomics chromosome genes genetics

Authors and affiliations

  • Friedrich Vogel
    • 1
  • Arno G. Motulsky
    • 2
  1. 1.Institut für Humangenetik und AnthropologieHeidelbergGermany
  2. 2.Division of Medical Genetics, School of MedicineUniversity of WashingtonSeattleUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-03356-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 1997
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-662-03358-6
  • Online ISBN 978-3-662-03356-2
  • About this book