Magnetic Resonance of Myelin, Myelination and Myelin Disorders

1. Mitochondria and Mitochondrial Disorders

   • Marjo S. van der Knaap, Jacob Valk

   Pages 140-145

2. Defects of Mitochondrial DNA

   • Marjo S. van der Knaap, Jacob Valk

   Pages 146-157

3. Leigh Syndrome

   • Marjo S. van der Knaap, Jacob Valk

   Pages 158-161

4. Pyruvate Carboxylase Deficiency

   • Marjo S. van der Knaap, Jacob Valk

   Pages 162-164

5. Cerebrotendinous Xanthomatosis

   • Marjo S. van der Knaap, Jacob Valk

   Pages 165-169

6. Refsum Disease

   • Marjo S. van der Knaap, Jacob Valk

   Pages 170-173

7. Nucleus, DNA, and DNA Repair

   • Marjo S. van der Knaap, Jacob Valk

   Pages 174-176

8. Cockayne’s Disease

   • Marjo S. van der Knaap, Jacob Valk

   Pages 177-183

9. Pelizaeus-Merzbacher Disease

   • Marjo S. van der Knaap, Jacob Valk

   Pages 184-189

10. 18q− Syndrome

    • Marjo S. van der Knaap, Jacob Valk

    Pages 190-191

11. Phenylketonuria

    • Marjo S. van der Knaap, Jacob Valk

    Pages 192-200

12. Glutaric Aciduria Type 1

    • Marjo S. van der Knaap, Jacob Valk

    Pages 201-204

13. Propionic Acidemia

    • Marjo S. van der Knaap, Jacob Valk

    Pages 205-207

14. Hyperprolinemia

    • Marjo S. van der Knaap, Jacob Valk

    Pages 208-208

15. Nonketotic Hyperglycinemia

    • Marjo S. van der Knaap, Jacob Valk

    Pages 209-210

16. Maple Syrup Urine Disease

    • Marjo S. van der Knaap, Jacob Valk

    Pages 211-215

17. Canavan’s Disease

    • Marjo S. van der Knaap, Jacob Valk

    Pages 216-219

18. L-2-Hydroxyglutaric Aciduria

    • Marjo S. van der Knaap, Jacob Valk

    Pages 220-222

19. Hyperhomocysteinemias

    • Marjo S. van der Knaap, Jacob Valk

    Pages 223-230

20. Urea Cycle Defects

    • Marjo S. van der Knaap, Jacob Valk

    Pages 231-236

The first edition of this book was well received by readers and reviewers and we are very grateful for the positive reactions. We were convinced then, and even more now, that MRI and MRS have much to offer in diagnosis, therapy monitoring and research of hereditary and acquired myelin disorders. In the last few years, a great deal of new information has come available, concern­ ing the genetic basis of inborn errors of metabolism and neurodegenerative disor­ ders, the role of subcellular structures, the enzyme biochemistry, the pathophysio­ logical mechanisms of posthypoxic-ischemic cerebral damage, and the inflammato­ ry processes in infectious and inflammatory disorders. MR images of many rare disorders have become available, either in our own experience or published by other groups. MR spectroscopy could confirm its role in certain clinical applica­ tions. Because of these developments, it was necessary for us to rewrite the book almost completely. In some fields developments are so fast that we may not have caught all the latest developments. The pattern of the new approaches has, however, been established, making the assimilation of newly available information easy. We are extremely grateful for the help of colleagues to make this book as com­ plete as possible. The positive reactions of those from whom we requested MR pictures or other forms of support were of enormous encouragement to us during our efforts to complete this project. We hope this work will be as warmly welcomed by our colleagues as the first edition.

• Hereditary and acquired white matter disorders
• Magnetic resonance of white matter disorders
• Myelin disorders
• Mylination
• White matter disorders
• biology
• classification
• genetics
• magnetic resonance
• magnetic resonance imaging (MRI)
• magnetic resonance spectroscopy
• molecular biology
• radiotherapy

"This book should receive very positive reactions, even more than the first edition. We are indebted to the authors for this magnificent work." European Neurology

• Department of Child Neurology, Free University Hospital, Amsterdam, The Netherlands

  Marjo S. Knaap

• Department of Diagnostic Radiology, Free University Hospital, Amsterdam, The Netherlands

  Jacob Valk

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