Magnetic Resonance of Myelin, Myelination and Myelin Disorders

1. Front Matter

   Pages i-xi

   PDF

2. Myelin and White Matter

   • Marjo S. van der Knaap, Jacob Valk

   Pages 1-17

3. Classification of Myelin Disorders

   • Marjo S. van der Knaap, Jacob Valk

   Pages 18-21

4. Selective Vulnerability

   • Marjo S. van der Knaap, Jacob Valk

   Pages 22-30

5. Myelination and Retarded Myelination

   • Marjo S. van der Knaap, Jacob Valk

   Pages 31-52

6. Lysosomes and Lysosomal Disorders

   • Marjo S. van der Knaap, Jacob Valk

   Pages 53-57

7. Metachromatic Leukodystrophy

   • Marjo S. van der Knaap, Jacob Valk

   Pages 58-64

8. Multiple Sulfatase Deficiency

   • Marjo S. van der Knaap, Jacob Valk

   Pages 65-67

9. Globoid Cell Leukodystrophy: Krabbe’s Disease

   • Marjo S. van der Knaap, Jacob Valk

   Pages 68-75

10. GM1 Gangliosidosis

    • Marjo S. van der Knaap, Jacob Valk

    Pages 76-80

11. GM2 Gangliosidosis

    • Marjo S. van der Knaap, Jacob Valk

    Pages 81-89

12. Fabry’s Disease

    • Marjo S. van der Knaap, Jacob Valk

    Pages 90-93

13. Fucosidosis

    • Marjo S. van der Knaap, Jacob Valk

    Pages 94-96

14. Mucopolysaccharidoses

    • Marjo S. van der Knaap, Jacob Valk

    Pages 97-105

15. Peroxisomes and Peroxisomal Disorders

    • Marjo S. van der Knaap, Jacob Valk

    Pages 106-109

16. Zellweger Cerebrohepatorenal Syndrome, Neonatal Adrenoleukodystrophy, and Infantile Refsum Disease

    • Marjo S. van der Knaap, Jacob Valk

    Pages 110-120

17. Rhizomelic Chondrodysplasia Punctata

    • Marjo S. van der Knaap, Jacob Valk

    Pages 121-123

18. Zellweger-like Syndrome

    • Marjo S. van der Knaap, Jacob Valk

    Pages 124-124

19. Pseudo-neonatal Adrenoleukodystrophy, Trifunctional Protein Deficiency, and Pseudo-Zellweger Syndrome

    • Marjo S. van der Knaap, Jacob Valk

    Pages 125-128

20. X-linked Adrenoleukodystrophy

    • Marjo S. van der Knaap, Jacob Valk

    Pages 129-139

The first edition of this book was well received by readers and reviewers and we are very grateful for the positive reactions. We were convinced then, and even more now, that MRI and MRS have much to offer in diagnosis, therapy monitoring and research of hereditary and acquired myelin disorders. In the last few years, a great deal of new information has come available, concern­ ing the genetic basis of inborn errors of metabolism and neurodegenerative disor­ ders, the role of subcellular structures, the enzyme biochemistry, the pathophysio­ logical mechanisms of posthypoxic-ischemic cerebral damage, and the inflammato­ ry processes in infectious and inflammatory disorders. MR images of many rare disorders have become available, either in our own experience or published by other groups. MR spectroscopy could confirm its role in certain clinical applica­ tions. Because of these developments, it was necessary for us to rewrite the book almost completely. In some fields developments are so fast that we may not have caught all the latest developments. The pattern of the new approaches has, however, been established, making the assimilation of newly available information easy. We are extremely grateful for the help of colleagues to make this book as com­ plete as possible. The positive reactions of those from whom we requested MR pictures or other forms of support were of enormous encouragement to us during our efforts to complete this project. We hope this work will be as warmly welcomed by our colleagues as the first edition.

• Hereditary and acquired white matter disorders
• Magnetic resonance of white matter disorders
• Myelin disorders
• Mylination
• White matter disorders
• biology
• classification
• genetics
• magnetic resonance
• magnetic resonance imaging (MRI)
• magnetic resonance spectroscopy
• molecular biology
• radiotherapy

"This book should receive very positive reactions, even more than the first edition. We are indebted to the authors for this magnificent work." European Neurology

• Department of Child Neurology, Free University Hospital, Amsterdam, The Netherlands

  Marjo S. Knaap

• Department of Diagnostic Radiology, Free University Hospital, Amsterdam, The Netherlands

  Jacob Valk

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