Molecular Aspects of Chemotherapy

Proceedings of the Third International Symposium on Molecular Aspects of Chemotherapy Gdańsk, Poland June 19–21, 1991

  • David Shugar
  • Wojciech Rode
  • Edward Borowski

Table of contents

  1. Front Matter
    Pages I-VIII
  2. B. J. Burke, K. Rowberg, M. G. Cardozo, M. G. Koehler, A. J. Hopfinger
    Pages 23-40
  3. B. Jastorff, E. Maronde, M. X. P. van Bemmelen, M. Zorn, R. Störmann
    Pages 73-104
  4. A. Garnier-Suillerot, F. Frezard, J. Tarasiuk
    Pages 105-117
  5. W. Fiers, R. Beyaert, P. Brouckaert, E. Decoster, D. De Valck, B. Everaerdt et al.
    Pages 119-125
  6. D. R. Tyreman, M. W. Smith, G. M. Payne, J. W. Payne
    Pages 127-142
  7. S. Jolidon, A. Polak-Wyss, P. G. Hartman, P. Guerry
    Pages 143-152
  8. G. D. Diana, A. M. Treasurywala, T. R. Bailey, R. C. Oglesby
    Pages 153-162
  9. Y-C. Cheng, C-N. Chang, S-L. Doong, G. E. Dutschman, C-H. Tsai, E. A. Murphy et al.
    Pages 231-238
  10. Back Matter
    Pages 271-279

About these proceedings

Introduction

While serendipity and random screening continue to fulfil a significant role in the search for new drugs, current remarkable advances in molecular biology and genetics are dictating to a profound extent the approaches employed in their development. Increasing attention is being devoted to investigations of the mechanisms of action of existing drugs, and the sources of undesired side effects, at the molecular level. The information so derived is now extensively applied, with the aid of broad inter­ disciplinary approaches, both theoretical and experimental, to improvements in existing drugs, and the rational design of new ones. The foregoing comprised the subject matter of the 3rd Inter­ national Symposium on "Molecular Aspects of Chemotherapy", under the auspices of the International Society of Chemotherapy, and organized by the Committee on Drug Research, Polish Academy of Sciences, and the Department of Biotechnology and Biochemistry, Technical University of Gdansk. This volume includes the texts of the review lectures presented by invited participants on up-to-date achievements, and future perspectives, in molecular mechanisms of inhibition of cellular functions and metabolism, with emphasis on the design and mechanisms of action of chemotherapeutic agents for treatment of bacterial, neoplastic, viral and parasitic diseases. From the Contents, it will be seen that the range of disciplines represented was a broad one, including theoretical and experimental chemists, physicists, molecular biologists, biochemists, enzymologists, virologists, tumour biologists. Plenary sessions were supple­ mented by several poster sessions.

Keywords

DNA Nucleotide activation antibiotics chemistry chemotherapy enzyme enzymes membrane transport metabolism protein proteins receptor tumor viruses

Editors and affiliations

  • David Shugar
    • 1
    • 2
    • 3
  • Wojciech Rode
    • 4
  • Edward Borowski
    • 5
  1. 1.Polish Academy of SciencesUniversity of WarsawWarsawPoland
  2. 2.Institute of Biochemistry & BiophysicsPolish Academy of ScienceWarszawaPoland
  3. 3.Department of Biophysics, Institute of Experimental PhysicsUniversity of WarsawWarszawaPoland
  4. 4.Nencki Institute of Experimental BiologyPolish Academy of SciencesWarszawaPoland
  5. 5.Department of Pharmaceutical Technology & BiochemistryTechnical University of GdańskGdańskPoland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-02740-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1992
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-662-02742-4
  • Online ISBN 978-3-662-02740-0
  • About this book