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  • Conference proceedings
  • © 1977

Atherosclerosis IV

Proceedings of the Fourth International Symposium

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Table of contents (136 papers)

  1. Front Matter

    Pages I-XLVI
  2. Relation Between Arterial Wall and Risk Factors for Coronary Heart Disease Connective Tissue and Immunological Mechanism on Atherosclerosis

    1. Front Matter

      Pages XLVII-XLVII
    2. Arterial Endothelial Permeability to Macromolecules

      • C. J. Schwartz, R. G. Gerrity, L. J. Lewis, G. M. Chisolm, K. N. Bretherton
      Pages 1-11
    3. The Maintenance of Endothelial Integrity

      • J. C. F. Poole
      Pages 12-15
    4. Arterial Smooth Muscle Cells in Atherogenesis: Births, Deaths and Clonal Phenomena

      • W. A. Thomas, J. M. Reiner, R. A. Florentin, K. Janakidevi, K. J. Lee
      Pages 16-23
    5. Lipoproteins — Steady State Aspects

      • Elspeth B. Smith
      Pages 24-29
    6. Connective Tissue in Atherosclerosis

      • M. Daria Haust
      Pages 30-35
    7. Immunologic Mechanism of Atherosclerosis

      • J. L. Beaumont, V. Beaumont
      Pages 36-44
    8. Dynamics of Lipoproteins and Lipids in the Arterial Wall

      1. Introduction
        • A. J. Day
        Pages 45-46
      2. Enzymes Catalyzing Phospholipid-Dependent Transacylations in the Arterial Wall
        • J. Patelski, M. Piorunska-Stolzmann, A. Waliszewska
        Pages 48-51
      3. Abstract
        • G. Schettler, Y. Goto, Y. Hata, G. Klose
        Pages 63-72
    9. Hypertension, Arteriolar Disease and Atherosclerosis

      1. Hypertension, Stroke and Atherogenesis in Experimental Models
        • Yukio Yamori, Ryohichi Horie, Michiya Ohtaka, Yasuo Nara, Masaichi Fukase
        Pages 79-83
      2. Hypertension and Cerebral Atherosclerosis
        • Y. Yoshida, H. Shinkai, T. Sekiguchi, G. Ooneda
        Pages 83-87
      3. Abstracts
        • G. Schettler, Y. Goto, Y. Hata, G. Klose
        Pages 88-91
    10. Epidemiology of Atherosclerosis and Geographic Differences in Risk Factors

      1. Association between Risk Factors and Atherosclerotic Lesions Based on Autopsy Findings in the Oslo Study: A Preliminary Report
        • Lars A. Solberg, Ingvar Hjermann, Anders Helgeland, Ingar Holme, Paul A. Leren, Jack P. Strong
        Pages 98-102

About this book

The presence of monotypism in thick atherosclerotic lesions of black females with G-6-PD mosaicism first reported by the Benditts (1973) has been confirmed in two other laboratories. However, we believe that it is premature to conclude that the finding of monotypism necessarily indicates monoclonal origin of athero­ sclerotic lesions. We have suggested two alternative explanations for the obser­ vation of monotypism which we believe must be shown to be invalid before accept­ ing monoclonal origin as the only plausible way to account for the observed G-6-PD monotypism. One of these two alternatives relates to clonal heterogeneity of cell growth potential, i. e. , during the course of progressive growth of a le­ sion, progeny of one cell may overgrow all others in a portion of the lesion. The other alternative is that one of the G-6-PD alleles may be linked to genes that afford a preferential survival characteristic in the abnormal environment present in atheroscerotic lesions. Thus, cells with one allele may be able to grow better than cells with the other allele, and this characteristic may be unrelated to "A-ness" or "B-ness". We have studied initiation of lesions in He diet-fed swine and demonstrated that all active lesions that were studied were of multiple cell origin (not monoclo­ nal). We have studied cell growth patterns in developing atherosclerotic lesions in He diet-fed swine and found evidence consistent with clonal heterogeneity in growth potential of lesion cells.

Keywords

  • Arterienverkalkung
  • Stent
  • atherosclerosis
  • cell
  • growth

Bibliographic Information

  • Book Title: Atherosclerosis IV

  • Book Subtitle: Proceedings of the Fourth International Symposium

  • Editors: G. Schettler, Y. Goto, Y. Hata, G. Klose

  • DOI: https://doi.org/10.1007/978-3-642-95308-8

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1977

  • Softcover ISBN: 978-3-642-95310-1

  • eBook ISBN: 978-3-642-95308-8

  • Edition Number: 1

  • Number of Pages: XLV, 797

  • Topics: Angiology

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • ISBN: 978-3-642-95308-8
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 109.00
Price excludes VAT (USA)