The Mechanism of Action of Androgens

  • W. Ian P. Mainwaring

Part of the Monographs on Endocrinology book series (ENDOCRINOLOGY, volume 10)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Introduction

    1. W. Ian P. Mainwaring
      Pages 1-4
  3. A Contemporary Model for the Mechanism of Action of Androgens

    1. Front Matter
      Pages 5-5
    2. W. Ian P. Mainwaring
      Pages 6-7
    3. W. Ian P. Mainwaring
      Pages 10-15
    4. W. Ian P. Mainwaring
      Pages 16-20
    5. W. Ian P. Mainwaring
      Pages 21-21
  4. The Metabolism of Androgens in Relation to Their Mechanism of Action

    1. Front Matter
      Pages 23-24
    2. W. Ian P. Mainwaring
      Pages 29-31
    3. W. Ian P. Mainwaring
      Pages 40-41
    4. W. Ian P. Mainwaring
      Pages 42-42
  5. Initial Events in the Mechanism of Action of Androgens

    1. Front Matter
      Pages 43-43
    2. W. Ian P. Mainwaring
      Pages 78-91
    3. W. Ian P. Mainwaring
      Pages 92-96
    4. W. Ian P. Mainwaring
      Pages 97-97

About this book

Introduction

My introduction to androgens was neither auspicious nor impressive. I was sitting my viva voce examination for a degree in physiology and had haltingly intimated to my examiner (name decorously withheld) that I intended to pursue a career in re­ search. "On what topic?" was the reply. I had been deeply impressed by the work of C. Huggins and C. V. Hodges (Cancer Res. 1, 293, 1941) on the dramatic arrest of canine prostatic hyperplasia by the administration of stilboestrol. With some en­ thusiasm, I responded, "On steroid hormones, because I am struck by the profound effects that may be achieved by relatively small numbers of molecules. " The examiner sank into deep contemplation before replying, "Young man, have you considered go­ ing into teaching?" Suitably chastened, I finally began my research career investigating the effects of steroids on the nucleic acid metabolism of experimental tumours and on the process cells. Reaching an impasse in this work, I mentioned one of senescence in animal day to Dr. G. F. Marrian that, somewhat surprisingly, we had no understanding of the fundamental mechanism of action of steroid hormones, especially the androgens. me to tackle this problem, particularly since exciting new insights He encouraged were then being made into the interaction of radioactively labelled oestradiol-l?,8 with such tissues as rat uterus.

Keywords

cancer hormone metabolism physiology steroid steroids

Authors and affiliations

  • W. Ian P. Mainwaring
    • 1
  1. 1.Androgen Physiology DepartmentImperial Cancer Research FundLondonGreat Britain

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-88429-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1977
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-88431-3
  • Online ISBN 978-3-642-88429-0
  • Series Print ISSN 0077-1015
  • About this book