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Rubidomycin

A New Agent against Cancer

  • Editors
  • J. Bernard
  • R. Paul
  • M. Boiron
  • Cl. Jacquillat
  • R. Maral

Table of contents

  1. Front Matter
    Pages I-XIV
  2. Introduction

    1. J. Bernard, R. Paul, M. Boiron, Cl. Jacquillat, R. Maral
      Pages 1-2
  3. History of Rubidomycin

    1. J. Bernard, R. Paul, M. Boiron, Cl. Jacquillat, R. Maral
      Pages 3-4
  4. Preparation and Experimental Investigation

    1. J. Bernard, R. Paul, M. Boiron, Cl. Jacquillat, R. Maral
      Pages 5-18
    2. J. Bernard, R. Paul, M. Boiron, Cl. Jacquillat, R. Maral
      Pages 18-24
    3. J. Bernard, R. Paul, M. Boiron, Cl. Jacquillat, R. Maral
      Pages 24-45
    4. J. Bernard, R. Paul, M. Boiron, Cl. Jacquillat, R. Maral
      Pages 46-62
    5. J. Bernard, R. Paul, M. Boiron, Cl. Jacquillat, R. Maral
      Pages 62-76
  5. Clinical and Therapeutic Study

    1. J. Bernard, R. Paul, M. Boiron, Cl. Jacquillat, R. Maral
      Pages 77-87
    2. J. Bernard, R. Paul, M. Boiron, Cl. Jacquillat, R. Maral
      Pages 87-101
    3. J. Bernard, R. Paul, M. Boiron, Cl. Jacquillat, R. Maral
      Pages 101-113
    4. J. Bernard, R. Paul, M. Boiron, Cl. Jacquillat, R. Maral
      Pages 113-125
    5. J. Bernard, R. Paul, M. Boiron, Cl. Jacquillat, R. Maral
      Pages 125-143
    6. J. Bernard, R. Paul, M. Boiron, Cl. Jacquillat, R. Maral
      Pages 144-155
    7. J. Bernard, R. Paul, M. Boiron, Cl. Jacquillat, R. Maral
      Pages 155-163
  6. Conclusions

    1. J. Bernard, R. Paul, M. Boiron, Cl. Jacquillat, R. Maral
      Pages 163-165
  7. Back Matter
    Pages 166-183

About this book

Introduction

Trials in the treatment of the leukemias are sometimes based on a hypothesis, as in the case of exchange transfusion [33] or the use of antimetabolites [86]. Or they are conducted empirically as the results of chance observations, as in the case of the use of the nitrogen mustards, urethane, and the Vinca alkaloids. Or they lie between the two, aiming at making use of well established biological facts: examples are the use of ACTH, cortisone and, more recently, the antibiotics. What is true for bacteria may also perhaps be true, if not for elephants, at least for the malignant cells of mammals. It was this idea that lay behind the first attempts at treating cancer and leukemia with antibiotics. The results obtained by the use of certain substances extracted from micro-organisms (actinomycin, azaserine, mito­ mycin, rufocromomycin), although encouraging at times, were inconsistent. The action of rubidomycin appears to cover a wider spectrum and to be more consistent and more effective. As in the case of Homer and Christopher Columbus, the honor of having given birth to rubidomycin is claimed by more than one country and town. In fact, the same product was discovered in the same year, though quite independently, by a group of French workers [184] who described it under the name of rubidomycin, and by a group of Italian workers [87] who studied it under the name of daunomycin.

Keywords

alkaloids antibiotics cancer leukemia

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-88125-1
  • Copyright Information Springer-Verlag Berlin Heidelberg 1969
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-88127-5
  • Online ISBN 978-3-642-88125-1
  • Series Print ISSN 0080-0015
  • Buy this book on publisher's site