Red Cell Shape

1. Front Matter

   Pages i-viii

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2. Red Cell Shapes and Nomenclature

   1. Red Cell Shapes. An Illustrated Classification and its Rationale

      • M. Bessis

      Pages 1-25

   2. Nomenclature of Red Cell Shapes A commentary

      • G. Brecher

      Pages 27-30

   3. Spiculed Erythrocytes after Splenectomy Acanthocytes or Non-Specific Poikilocytes ?

      • G. Brecher, J. E. Haley, R. O. Wallerstein

      Pages 31-34

3. Discocyte-Echinocyty and Discocyte-Stomatocyte Transformations

   1. Erythrocyte Shape Alteration « In Vitro » : Relationship to Plasma and Cellular Factors Abstract

      • M. A. Lichtman, G. V. Marinetti

      Pages 35-36

   2. The Role of Lysolecithin Formed in Plasma on the Discocyte-Echinocyte Transformation A commentary

      • C. Feo

      Pages 37-40

   3. Red Cell Membrane Shape and Stability : Relation to Cell Lipid Renewal Pathways and Cell ATP

      • S. B. Shohet, J. E. Haley

      Pages 41-50

   4. Quantitative Study of Factors which Control Shape Transformations of Human Red Blood Cells of Constant Volume

      • J. F. Hoffman

      Pages 51-54

   5. Calcium-pH Interactions in the Production of Shape Change in Erythrocytes

      • R. I. Weed, B. Chailley

      Pages 55-68

   6. Membrane Fragmentation and Ca++-Membrane Interaction : Potential Mechanisms of Shape Change in the Senescent Red Cell

      • P. L. La Celle, F. H. Kirkpatrick, M. P. Udkow, B. Arkin

      Pages 69-78

   7. Divalent Cation Content of Normal and ATP-Depleted Erythrocytes and Erythrocyte Membranes

      • M. A. Lichtman, R. I. Weed

      Pages 79-93

4. Biophysical Studies and Membrane Models

   1. The Discocyte — Echinocyte Transformation of the Human Red Cell : Deformability Characteristics

      • P. Leblond

      Pages 95-104

   2. Hemolysis, Induced by Pulsed Laser Irradiation, Transmitted along Rouleaux of Human Red Blood Cells

      • P. B. Canham

      Pages 105-113

   3. Red Cell Biconcavity and Deformability A macromodel based on flow chamber observations

      • B. Bull

      Pages 115-124

   4. A Simple Flow Chamber for Hydraulic Manipulation of Individual Cells

      • B. Bull

      Pages 125-129

   5. Image Holograms of Single Red Blood Cell Discocyte-Spheroechinocyte Transformations

      • E. A. Evans, P. F. Leblond

      Pages 131-140

   6. Image Processing Techniques in Relation to Studies of Red Cell Shape

      • M. Eden

      Pages 141-149

5. Membrane Ultrastructure: Freeze-Cleave and Freeze-Etch Studies

   1. Membrane Ultrastructure of Normal, Sickled and Heinz-Body Erythrocytes by Freeze-Etching

      • L. S. Lessin

      Pages 151-168

   2. Pits in the Freeze-Cleavage Plane of Normal Erythrocyte Membranes; and Ultrastructure of Membrane Lesions in Immune Lysis

      • P. Seeman, G. H. Iles

      Pages 169-180

This monograph is a collection of invited contributions from a group of investiga­ tors who share a common interest in the interrelationships between the shape, struc­ ture, and functional characteristics of normal and pathologic erythrocytes. Most of the authors participated in a workshop on red cell shape held in June, 1972 at the Institute of Cell Pathology, Hopital de Bicetre, Paris. We hope that these various contributions on the physiology, pathology, and ultrastructure of red cell shape will be useful and stimulating for other investigators interested in the correlation of shape and structure with the biochemistry and biophysics of the red cell. The text is divided into four sections. Section I deals with red cell shape, including the presentation of a rational descriptive nomenclature and a discussion of post­ splenectomy changes. Section II deals with biochemical factors that underlie the disco­ cyte-echinocyte (crenated) and discocyte-stomatocyte (cup-shaped) transformation. This section includes discussions of plasma factors, and of the biochemical dynamics of erythrocyte lipids and consideration of the effects of such factors as cellular ATP, calcium, aging, and various chemical agents as determinants of shape. Section III, which deals with biophysical measurements, includes studies of the deformability of cells of different shapes, descriptions of ways to define precisely the geometric dimensions of the red cell under various circumstances, and a model of membrane structure, which is proposed to account for the dimensions of red cells that undergo shape change.

• Rotes Blutkörperchen
• Rotes Blutkörperchen /Erkrankung
• biochemistry
• cell
• chemistry
• nomenclature
• pathology
• physics
• physiology
• plasma

• Institut de Pathologie Cellulaire, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France

  Marcel Bessis, Pierre F. Leblond

• Depts. of Medicine and of Radiation Biology and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, USA

  Robert I. Weed

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