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Intracellular Regulation of Ion Channels

  • Martin Morad
  • Zalman Agus

Part of the NATO ASI Series book series (volume 60)

Table of contents

  1. Front Matter
    Pages I-X
  2. Regulation of K+ Channels

    1. Front Matter
      Pages 1-1
    2. O. Pongs
      Pages 3-8
    3. Arthur M. Brown
      Pages 9-13
    4. W. M. Kwok, L. C. Freeman, J. Anumonwo, R. S. Kass
      Pages 27-42
    5. E. Carmeliet, H.-N. Luk
      Pages 53-59
    6. N. B. Standen, N. W. Davies, A. Pettit, P. R. Stanfield
      Pages 61-69
    7. James N. Weiss, Nagammal Venkatesh, Nicholas A. Deutsch
      Pages 71-81
    8. M. Lazdunski, M. Fosset, J. De Weille, E. Honoré, C. Mourre
      Pages 83-86
  3. Regulation of Ca2+ Channels

    1. Front Matter
      Pages 87-87
    2. F. Hofmann, M. Biel, R. Hullin, E. Bosse, V. Flockerzi
      Pages 89-97
    3. M. Marlene Hosey, Rebecca M. Brawley, Chan Fong Chang, Luis Miguel Gutierrez, Cecilia Mundina-Weilenmann, Jianjie Ma et al.
      Pages 99-106
    4. A. Cavalié, T. J. A. Allen, W. Trautwein
      Pages 107-112
    5. S. Pelzer, Y. M. Shuba, L. Birnbaumer, T. F. McDonald, D. J. Pelzer
      Pages 113-127
    6. H. D. Lux, N. Tokutomi, F. Grassi
      Pages 141-151
    7. J. Hescheler, C. Kleuss, C. Ewel, B. Wittig, W. Rosenthal, G. Schultz
      Pages 153-159
    8. Daniela Pietrobon, Lia Forti, Peter Hess
      Pages 173-180
    9. Robert S. Zucker
      Pages 191-201
    10. Masaki Kameyama, Asako Kameyama, Emiko Takano, Kazuto Yazawa, Kenji Yasui, Takashi Murachi
      Pages 203-206
  4. Regulation of Na+, Cl−, and If Channels

    1. Front Matter
      Pages 207-207
    2. William A. Catterall, Todd Scheuer, Randal Numann, Ming Li, James West, Brian Murphy et al.
      Pages 209-219
    3. Robert D. Harvey, Jonas A. Jurevičius, Joseph R. Hume
      Pages 221-229
    4. Zalman S. Agus, Ellie Kelepouris, lain Dukes, Richard Kasama, Martin Morad
      Pages 231-239
  5. Back Matter
    Pages 247-254

About these proceedings

Introduction

Understanding the molecular processes by which ionic channels are regulated is central to the understanding of cellular function. Great advances in understanding these regulatory mechanisms have been recently achieved by the combination of several powerful techniques. Development of the patch clamp technique, ability to access the intracellular channels sites, and genetic manipulation of channel structure have allowed studies of channel function in native membranes. Cloning, sequencing and determining the channel structure and its subunits allows further insight into the regulatory mechanisms of channel function. In planning this symposium, we organized the scientific discussions around specific molecular topics independent of the tissue and species of origin. Clearly, the subject of ion channel regulation is multi-faceted, with a large number of very talented scientists working in the field. The NATO Symposium represented an attempt to bring together these individuals and synthesize and evaluate new ideas and experimental findings. A great deal of novel data was presented, and scientific insight into the molecular processes which regulate ionic channels was furthered. This book gives a synopsis of the scientific presentations and is organized into 3 sections. The first section deals with the diversity of K + channels and their regulation, including structure-function and mechanistic studies. Presentations dealt with the characterization and modulation of a variety ofK+ channels in cardiac and neuronal cells, including ATP­ dependent K+ channels, Na + -activated K+ channels, delayed rectifier K+ channels and the diversity of their regulation by G-proteins.

Keywords

ATP Calcium Insulin Regulation kinetics muscle neurons pharmacology phosphorylation physiology protein proteins receptor system tissue

Editors and affiliations

  • Martin Morad
    • 1
  • Zalman Agus
    • 1
  1. 1.School of Medicine, Dept. of PhysiologyUniversity of PennsylvaniaPhiladelphiaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-84628-1
  • Copyright Information Springer-Verlag Berlin Heidelberg 1992
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-84630-4
  • Online ISBN 978-3-642-84628-1
  • Buy this book on publisher's site