Urinary Enzymes

in Clinical and Experimental Medicine

  • Klaus Jung
  • Hermann Mattenheimer
  • Ulf Burchardt

Table of contents

  1. Front Matter
    Pages i-xviii
  2. Biochemical, Pathobiochemical, and Morphological Fundamentals of the Excretion of Urinary Enzymes

    1. Front Matter
      Pages 1-1
    2. H. Mattenheimer, U. Burchardt
      Pages 3-7
    3. U. Burchardt, J. E. Scherberich
      Pages 21-41
    4. W. Rebel, T. Bertsch, G. Bode, H. Bleuel
      Pages 43-72
    5. U. Burchardt, K. Jung
      Pages 73-86
  3. Methodological Fundamentals of the Activity Determination of Urinary Enzymes

    1. Front Matter
      Pages 87-87
    2. H. Mattenheimer, D. Maruhn
      Pages 89-95
    3. Z. J. Simane
      Pages 97-98
    4. H. Mattenheimer, K. Jung, H. Grötsch, Z. J. Simane, J. E. Scherberich, A. S. Bhargava et al.
      Pages 99-145
    5. K. Jung, D. Maruhn
      Pages 147-152
    6. K. Jung
      Pages 153-160
  4. Urinary Enzymes in Clinical Medicine

    1. Front Matter
      Pages 161-161
    2. J. E. Scherberich
      Pages 163-167
    3. K. Jung, P. Kotanko
      Pages 189-202
    4. R. G. Price, P. H. Whiting
      Pages 203-221
    5. U. Burchardt, J. E. Scherberich
      Pages 223-244
  5. Urinary Enzymes in Animal Experiments

    1. Front Matter
      Pages 245-245

About this book

Introduction

Interest and research in urinary enzymology were incited about three decades ago by reports that urinary enzymes are elevated in diseases of the kidney and urinary tract. Of the more than 40 hydrolases, oxidoreductases, transferases, and lyases identified in human and animal urine, only ten or so are being used as diagnostic indicators. Recognition of the quantitative distribution of enzymes in the various anatomical and functional parts of the nephron and advances in our understanding of the handling of proteins by the kidney have made it possible to associate urinary enzyme activity patterns with physiological and pathophysio­ logical functions of the nephron. Confidence in the diagnostic value of urinary enzymes is not unanimous among clinicians and among scientists. The main reason for the difference in opinion may well be that the variability in data exceeds the variability one is accustomed to in the diagnostic enzymology of blood plasma enzymes. In contrast to plasma enzymes, which are protected by an "enzyme friendly" milieu, enzymes released into the urine encounter an "enzyme hostile" environ­ ment: no or little protective protein, variable pH, variable volume, variable metabolite and salt concentrations, variable concentrations of enzyme in­ hibitors. Through advances in methodology some of these factors can now be controlled; standardization of urine collection periods and preanalytical treat­ ment are as important as optimization of assay methods.

Keywords

Enzymdiagnostik Nierenerkrankung Urin diagnostics enzymes infection kidney medicine nephrotoxicity pathophysiology quality assurance renal disorders surgery transplantation urine

Editors and affiliations

  • Klaus Jung
    • 1
  • Hermann Mattenheimer
    • 2
  • Ulf Burchardt
    • 3
  1. 1.Department of Experimental Organ TransplantationUniversity Hospital Charité Humboldt University BerlinBerlinGermany
  2. 2.Department of BiochemistryRush-Presbyterian-St. Luke’s Medical CenterChicagoUSA
  3. 3.Department of MedicineDistrict Hospital FrankfurtFrankfurt (Oder)Germany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-84313-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1992
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-84315-0
  • Online ISBN 978-3-642-84313-6
  • About this book