Gastric Inhibitory Polypeptide

  • John Canvin Brown

Part of the Monographs on Endocrinology book series (ENDOCRINOLOGY, volume 24)

Table of contents

  1. Front Matter
    Pages I-XI
  2. John Canvin Brown
    Pages 1-11
  3. John Canvin Brown
    Pages 12-19
  4. John Canvin Brown
    Pages 20-33
  5. John Canvin Brown
    Pages 34-50
  6. John Canvin Brown
    Pages 51-53
  7. John Canvin Brown
    Pages 54-69
  8. John Canvin Brown
    Pages 70-72
  9. Back Matter
    Pages 73-90

About this book

Introduction

Dr. Raymond Pederson, Dr. Jill Dryburgh and I commenced work on GIP in 1968, when, with the generous help of Professor Viktor Mutt and Professor Erik Jorpes of the Karolinska Inst,itute, Stockholm, we were able to establish that there existed an inhibitory material for acid secretion in cholecystokinin-pancreozymin prepara­ tions. Once the physiological evidence for the inhibitor was established it seemed appropriate to seek help in its isolation. Dr. J. Dryburgh and Dr. R. Pederson were left to bioassay fractions in Vancouver whilst I enjoyed the company of Professor Mutt at the Karolinska for one year, as a Medical Research Council of Canada Visiting Scientist. Purification of the inhibitory factor proceeded rapidly due, in no small measure, to Professor Mutt's untirmg efforts on my behalf. Later that year, Dr. Dryburgh joined us in Stockholm to begin the sequence work on GIP. This was completed late in 1970 in Vancouver. In Stockholm in June 1970, I met a fellow Canadian Dr. John Dupre (McGill University) at a cocktail party who kept commenting about the possibility of GIP being an insulinotropic hormone, the "incretin" of earlier days. At that time, gastrointestinal physiologist as I was, I did not recognize the importance of his comment. This became apparent two or three years later when Dr. Dupre demonstrated that GIP was insulinotropic in man. In 1972, Maryanne Kuzio and Dr.

Keywords

Gastric inhibitory polypeptide biosynthesis cholecystokinin diabetes diabetes mellitus glucagon hormone insulin obesity pathophysiology physiology research tissue

Authors and affiliations

  • John Canvin Brown
    • 1
  1. 1.Department of PhysiologyUniversity of British ColumbiaVancouverCanada

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-81771-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 1982
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-81773-1
  • Online ISBN 978-3-642-81771-7
  • Series Print ISSN 0077-1015
  • About this book