Hirsutism

  • Pierre Mauvais-Jarvis
  • Frédérique Kuttenn
  • Irène Mowszowicz

Part of the Monographs on Endocrinology book series (ENDOCRINOLOGY, volume 19)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Pierre Mauvais-Jarvis, Frédérique Kuttenn, Irène Mowszowicz
    Pages 1-1
  3. Pierre Mauvais-Jarvis, Frédérique Kuttenn, Irène Mowszowicz
    Pages 2-3
  4. Pierre Mauvais-Jarvis, Frédérique Kuttenn, Irène Mowszowicz
    Pages 4-10
  5. Pierre Mauvais-Jarvis, Frédérique Kuttenn, Irène Mowszowicz
    Pages 11-14
  6. Pierre Mauvais-Jarvis, Frédérique Kuttenn, Irène Mowszowicz
    Pages 15-15
  7. Pierre Mauvais-Jarvis, Frédérique Kuttenn, Irène Mowszowicz
    Pages 16-17
  8. Pierre Mauvais-Jarvis, Frédérique Kuttenn, Irène Mowszowicz
    Pages 18-30
  9. Pierre Mauvais-Jarvis, Frédérique Kuttenn, Irène Mowszowicz
    Pages 31-42
  10. Pierre Mauvais-Jarvis, Frédérique Kuttenn, Irène Mowszowicz
    Pages 43-59
  11. Pierre Mauvais-Jarvis, Frédérique Kuttenn, Irène Mowszowicz
    Pages 60-73
  12. Pierre Mauvais-Jarvis, Frédérique Kuttenn, Irène Mowszowicz
    Pages 74-82
  13. Pierre Mauvais-Jarvis, Frédérique Kuttenn, Irène Mowszowicz
    Pages 83-91
  14. Back Matter
    Pages 92-110

About this book

Introduction

In the past 10 years hirsutism has been the object of a considerable number of fundamental studies. It provides endocrinologists with an experimental model for the investigation of androgen secretion, metabolism and mechanism of action. Plasma androgen assay, free testosterone measurement, hepatic and extrahepatic androgen metabolic clearance and androgen metabolism in the skin are the different steps which were studied by many groups and represent valuable parameters of the mechanisms of hirsutism. Determination of the origin of androgen oversecretion has become easier by technical progress in differential effiuent venous catheterism, which makes it possible to compare androgens in adrenal or ovarian effiuent veins to their peripheral levels, and to determine the ovarian or adrenal source of the androgen oversecretion as well as the side responsible, essential in the case of tumors. The study of androgen metabolism and the discovery of androgen receptors in the skin confIrm the latter as an actual target cell for androgens. This target cell uses the circulating active androgen, i. e. , testosterone and can also metabolize local inactive androgens into active ones. This is the case of androstenedione and dehy­ droepiandrosterone which are the two main androgens secreted in women, since women secrete very little testosterone. The capacity of the skin to transform inactive androgens into active ones varies from one individual to another. That would support the concept of variable skin receptivity from one woman to another and from one ethnic group to another.

Keywords

Hirsutismus cell hormone hypersensitivity metabolism pathophysiology physiology plasma protein skin steroid steroids therapy tumor women

Authors and affiliations

  • Pierre Mauvais-Jarvis
    • 1
    • 2
  • Frédérique Kuttenn
    • 1
    • 2
  • Irène Mowszowicz
    • 1
    • 2
  1. 1.Department of Reproductive EndocrinologyHôpital NeckerParis Cedex 15France
  2. 2.Department of BiochemistryFaculty of Medicine Pitié-SalpétrièreParis Cedex 13France

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-81571-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 1981
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-81573-7
  • Online ISBN 978-3-642-81571-3
  • Series Print ISSN 0077-1015
  • About this book