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Lymphocytes, Macrophages, and Cancer

  • Georges Mathé
  • Irène Florentin
  • Marie-Christine Simmler

Table of contents

  1. Front Matter
    Pages I-IX
  2. G. Stathopoulos, A. J. S. Davies
    Pages 17-23
  3. J. P. Levy, E. Gomard, A. Senik, J. C. Leclerc
    Pages 24-30
  4. I. Florentin, M. Bruley-Rosset, M. Davigny
    Pages 49-57
  5. A. C. Allison, G. Gregoriadis
    Pages 58-64
  6. M. Boranič, M. Poljak-Blaži, M. Radačić, J. Gabrilovac, I. Hršak
    Pages 79-86
  7. M. Seligmann, J. L. Preud’homme, J. C. Brouet
    Pages 91-97
  8. Back Matter
    Pages 161-162

About this book

Introduction

Fresh living Bacillus Calmette-Guerin (BeG), injected i.v. into (C57BI/ 6xDBA/2)FI mice, activated peritoneal macrophages rendering them highly cytotoxic for tumor cells in vitro. This cytotoxic activity w~s already maximal 14 days after injection of 1 mg of BCG and remained stable when 3 or 5 mg of BCG were given. At the same time spleen cells of the BCG-treat~d mice showed strongly depressed responses to the T-cell mitogens,PHA and Con A, irrespective of the dose of BCG injected. The inhibitory effect was shown to be mediated by suppressor cells which had characteristics of macrophages since they could be removed by carbonyl iron and magnet treatment and were adherent to plastic. In contrast to it was observed after injec­ tion of 1 mg of BCG, these suppressor cells alone did not account for the depression of T-cell re.sponses induced by higher doses of BCG. Nylon-nonadherent cell populations obtained from spleen cells treated with 3 or 5 mg BCG partially retained the inhibitory activity suggesting that suppressor T cells were also induced after injection of high doses of BCG. In contrast, the responses to the B-cell mitogen LPS of unfractionated and macrophage-depleted spleen cells were not affected or significantly enhanced depending on the dose of BCG injected.

Keywords

cancer cell lymphocytes macrophages neoplasm tumor

Editors and affiliations

  • Georges Mathé
    • 1
  • Irène Florentin
    • 1
  • Marie-Christine Simmler
    • 1
  1. 1.Institut de Cancérologie et d’Immunogénétique (INSERM)Hôpital Paul-BrousseVillejuifFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-81049-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 1976
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-81051-0
  • Online ISBN 978-3-642-81049-7
  • Series Print ISSN 0080-0015
  • Buy this book on publisher's site