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Tracer Methods in Hormone Research

  • Erlio Gurpide

Part of the Monographs on Endocrinology book series (ENDOCRINOLOGY, volume 8)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Erlio Gurpide
    Pages 1-4
  3. Erlio Gurpide
    Pages 29-43
  4. Erlio Gurpide
    Pages 44-70
  5. Erlio Gurpide
    Pages 71-104
  6. Erlio Gurpide
    Pages 165-175
  7. Back Matter
    Pages 176-190

About this book

Introduction

The purpose of this monograph is to describe theoretical aspects of the interpretation of data obtained from experiments performed with labeled hormones. Quantitative endocrinologic studies involving the use of tracers include the determination of rates at which hormones are secreted by endocrine glands and are produced outside these glands by conversion of other secreted hor­ mones. Tracer experiments are also performed with the purpose of measuring rates of metabolic reactions. These measurements reveal the contribution of secreted hormones to the formation of circulating compounds and urinary metabolites. The estimation of rates of fetal and placental production and exchange of hormones characterizes a class of in vivo quantitative studies performed with isotopically labeled hormones (radioactive or not). In addi­ tion, tracers are used to measure permeability and rates of reaction in in vitro systems, and to study the uptake of hormones by tissues, both in vivo and in vitro. The stability of the steroid nucleus carrying the isotopic label and the large number of reversible metabolic reactions in which steroids are involved, both facilitated and motivated the development of a sophisticated theoretical treat­ ment of tracer experiments in the field of endocrinology. Although the prac­ tical examples used to illustrate the concepts and calculations presented in this monograph involve labeled hormones, the theory is presented in a general symbolic manner and is applicable to other fields of investigation.

Keywords

Termination hormone steroid steroids tissue

Authors and affiliations

  • Erlio Gurpide
    • 1
  1. 1.Mount Sinai School of MedicineCity University of New YorkNew YorkUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-80892-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1975
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-80894-4
  • Online ISBN 978-3-642-80892-0
  • Series Print ISSN 0077-1015
  • Buy this book on publisher's site