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Hemoglobin

Cooperativity and Electronic Properties

  • Book
  • © 1974

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Authors:
  1. Mitchel Weissbluth

    1. Department of Applied Physics and W. W. Hansen Laboratories of Physics, Standford University, Standford, USA

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Table of contents (9 chapters)

  1. Front Matter

    Pages 3-VIII
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  2. Amino Acids, Peptides and Proteins

    • Mitchel Weissbluth
    Pages 1-9

  3. Hemoglobin

    • Mitchel Weissbluth
    Pages 10-26

  4. Oxygenation Characteristics

    • Mitchel Weissbluth
    Pages 27-41

  5. Approaches to Cooperativity

    • Mitchel Weissbluth
    Pages 42-57

  6. Electronic States of Iron

    • Mitchel Weissbluth
    Pages 58-92

  7. Magnetic Properties

    • Mitchel Weissbluth
    Pages 93-124

  8. Molecular Orbitals and Optical Spectra

    • Mitchel Weissbluth
    Pages 125-141

  9. Mossbauer Spectroscopy

    • Mitchel Weissbluth
    Pages 142-163

  10. Further Aspects

    • Mitchel Weissbluth
    Pages 164-168

  11. Back Matter

    Pages 169-175
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Keywords

About this book

Approximately one third of the mass of a mammalian red blood cell is hemo­ globin. Its major function is to bind oxygen at the partial pressure prevailing in the lungs and to release it to the tissues where the partial pressure is lower. The process whereby hemoglobin performs this essential physiological role is characterized by a cooperative interaction among its constituent subunits. A great deal of research effort has been devoted to this interaction, going back at least as far as the fitst decade of this century. Moreover, cooperativity in hemo­ globin is probably not unique; it may well be one instance of a general class of interactions that occur in biological molecules. Certain enzymes with a variety of regulatory and catalytic functions, for example, contain several sites which interact in a highly specific manner such that the affinity of a given site for the substrate is markedly influenced by the state of binding at the other sites. But whereas we know very little of the structure of most enzymes of this type, hemo­ globin is one of a very small number of biological molecules whose immensely intricate machinery has been revealed to us. We owe this insight to the group under the leadership of M. F. PERUTZ in Cambridge, England, whose research over a period of several decades culminated in a detailed description of the three­ dimensional structure.

Authors and Affiliations

  • Department of Applied Physics and W. W. Hansen Laboratories of Physics, Standford University, Standford, USA

    Mitchel Weissbluth

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