Tubulointerstitial and Cystic Disease of the Kidney

  • Susan M. Dodd

Part of the Current Topics in Pathology book series (CT PATHOLOGY, volume 88)

Table of contents

  1. Front Matter
    Pages I-XI
  2. P. D. Wilson, D. Falkenstein
    Pages 1-50
  3. G. Wolf, E. G. Neilson
    Pages 69-97
  4. B. Iványi, S. Olsen
    Pages 117-143
  5. N. Marcussen
    Pages 145-174
  6. F. N. Ziyadeh, S. Goldfarb
    Pages 175-201
  7. Back Matter
    Pages 289-294

About this book

Introduction

Over recent years, much renal research has focused on the pathology of the glomerulus, where many primary renal insults occur. However, nearly thirty years have passed since Risdon's study made the apparently anomalous observation that the extent of damage to the tubulointerstitial compartment is the major determinant of renal outcome in a variety of human glomerular diseases. This volume covers various aspects of tubulointerstitial disease, and starts with an update on cystic disease of the kidney, by Drs. WILSON and FALKENSTEIN, which includes recent experimental data on the altered properties of cystic epithelium. My own chapter gives an overview of the mechanisms of tubulo­ interstitial damage in progressive renal disease and includes a dis­ cussion of the possible role of cytokines, vasoactive peptides and peptide growth factors found over the last few years to be secreted by renal tubular cells. These comments are expanded in the contribution by Dr. WOLF and Professor NEILSON, who provide a detailed account of the cellular biology of tubulointerstitial growth. The earliest studies from the 19608 attempted to correlate histo­ morphometry of the tubulointerstitium with renal outcome. Dr. KHAN and Professor SINNIAH provide us with an update on mor­ phometric methods as applied to the kidney using new techniques. Similar techniques are employed by Dr. IVANYI and Professor OLSEN who give a detailed stereomorphological account of tubulitis both in acute allograft rejection, where its- recognition is central to the diagnosis, and in other forms of tubulointerstitial disease.

Keywords

Cyst Fibrosis Kidney Tubulointerstitium biology cell medicine molecular biology pathogenesis pathology research

Editors and affiliations

  • Susan M. Dodd
    • 1
    • 2
  1. 1.The London Hospital Medical CollegeUniversity of LondonLondonGreat Britain
  2. 2.Department of Morbid AnatomyThe Royal London HospitalLondonGreat Britain

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-79517-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1995
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-79519-0
  • Online ISBN 978-3-642-79517-6
  • Series Print ISSN 0070-2188
  • About this book