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Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates

  • Book
  • © 1994

Overview

Editors:
  1. W. E. G. Müller

    1. Institut für Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universität Mainz, Mainz, Germany

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  2. H. C. Schröder

    1. Institut für Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universität Mainz, Mainz, Germany

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Part of the book series: Progress in Molecular and Subcellular Biology (PMSB, volume 14)

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Table of contents (15 chapters)

  1. Front Matter

    Pages I-XV
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  2. Activation of the dsRNA-Dependent Kinase

    • R. A. Petryshyn, J. Li, R. Judware
    Pages 1-14

  3. Double-Stranded RNAs as Gene Activators

    • S. Landolfo, M. Gariglio, G. Gribaudo, G. Garotta
    Pages 15-27

  4. Viral-Dependent Phosphorylation of a dsRNA-Dependent Kinase

    • D. A. Roth, X. He
    Pages 28-47

  5. Cellular Inhibitors of the Interferon-Induced, dsRNA-Activated Protein Kinase

    • T. G. Lee, M. G. Katze
    Pages 48-65

  6. Mechanism of the Antiretroviral Effect of dsRNA

    • W. E. G. Müller, H. Ushijima, H. C. Schröder
    Pages 66-88

  7. The Antiviral Activity of RNA-Dye Combinations

    • J. M. Jamison, J. Gilloteaux, J. L. Summers
    Pages 89-113

  8. Chemical Synthesis of 2′,5′-0ligoadenylate Analogues

    • R. Charubala, W. Pfleiderer
    Pages 114-138

  9. Homologies Between Different Forms of 2-5A Synthetases

    • E. Truve, M. Kelve, A. Aaspollu, H. C. Schröder, W. E. G. Müller
    Pages 139-149

  10. 2-5A and Virus Infection

    • N. Fujii
    Pages 150-175

  11. The 2-5A System and HIV Infection

    • H. C. Schröder, M. Kelve, W. E. G. Müller
    Pages 176-197

  12. 2′,5′-0ligoadenylate Synthetase in Autoimmune BB Rats

    • V. Bonnevie-Nielsen
    Pages 198-208

  13. Oligoadenylate and Cyclic AMP: Interrelation and Mutual Regulation

    • A. V. Itkes
    Pages 209-221

  14. Regulation of HIV Replication in Monocytes by Interferon

    • J. A. Turpin, S. X. Fan, B. D. Hansen, M. L. Francis, L. M. Baca-Regen, H. E. Gendelman et al.
    Pages 222-241

  15. Transmembrane Signaling by IFN-α

    • L. M. Pfeffer, S. N. Constantinescu, C. Wang
    Pages 242-259

  16. Photolabeling of the Enzymes of the 2-5A Synthetase/RNase L/p68 Kinase Antiviral Systems with Azido Probes

    • R. J. Suhadolnik
    Pages 260-275
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Keywords

About this book

Biological response modifiers are increasingly used in viral and cancer therapy. Since alterations of the immune system are the primary symptoms of HIV infection, especially therapies directed towards the modulation of the immune response have been under intense evaluation. This volume summarizes current knowledge of the interferon-based natural antiviral protection system including 2',5'-oligoadenylate and double-stranded RNA. It will also help to develop further a solid scientific rationale for the practical use of heterologous immunomodulators in the clinics.

Editors and Affiliations

  • Institut für Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universität Mainz, Mainz, Germany

    W. E. G. Müller, H. C. Schröder

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