Growth Hormone and Somatomedins during Lifespan

1. Front Matter

   Pages I-XV

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2. Growth Hormone

   1. Front Matter

      Pages 1-1

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   2. Growth Hormone: Neural Mechanisms of Control at Neonatal and Aged Periods

      • V. Locatelli, S. G. Cella, D. Cocchi, V. Gennaro De Colonna, E. Giavini, M. Parenti et al.

      Pages 3-18

   3. Studies on Peptide 23: A GHRH-Regulated Protein of the Pituitary and Gastrointestinal Tract

      • N. Katsumata, C. Chakraborty, H. G. Friesen

      Pages 19-25

   4. Biochemistry and Cellular Distribution of the Growth Hormone Receptor

      • M. J. Waters, S. W. Rowlinson, K. S. Gobius, P. E. Lobie, J. Garcia-Aragon, G. E. Muscat et al.

      Pages 26-43

   5. Cellular Transfection of GH Receptor cDNA to Study GH Action

      • G. Norstedt, C. Carter-Su, S. Enerbäck, B. Enberg, G. Bjursell, S. Francis et al.

      Pages 44-51

3. Somatomedins

   1. Front Matter

      Pages 53-53

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   2. Molecular Biology of the Somatomedins

      • M. L. Adamo, D. LeRoith, C. T. Roberts Jr.

      Pages 55-64

   3. Tissue Expression of Insulin-like Growth Factor I

      • J. Isgaard, A. Nilsson, C. Ohlsson, A. Lindahl, H. Wåhlander, P. Friberg et al.

      Pages 65-71

   4. Insulin-like Growth Factor Receptors and Signaling Mechanisms

      • P. Nissley, W. Lopaczynski

      Pages 72-87

   5. Regulation of Insulin-like Growth Factor-I by Nutrition

      • J. M. Ketelslegers, J. P. Thissen, D. Maiter, T. Fliesen, T. Mauerhoff, S. Triest et al.

      Pages 88-99

   6. Insulin-like Growth Factor Binding Proteins: Biochemical Characterization

      • R. C. Baxter

      Pages 100-108

   7. Role of Insulin-like Growth Factor Binding Proteins in Modulating Insulin-like Growth Factor Action

      • D. R. Clemmons

      Pages 109-116

   8. Autocrine and Paracrine Effects of Insulin-like Growth Factors and Their Binding Proteins

      • F. Minuto, A. Barreca, G. Giordano

      Pages 117-128

4. Fetal and Neonatal Growth

   1. Front Matter

      Pages 129-129

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   2. Use of Transgenic and Genetic Models to Study the Neuroendocrine Regulation of Growth Hormone Secretion

      • L. A. Frohman, T. R. Downs, M. Sato

      Pages 131-140

   3. Biosynthesis and Biological Role of Insulin-like Growth Factors in the Nervous System

      • V. R. Sara, C. Ayer-Le Lievre, C. Carlson-Skwirut, K. Drakenberg, M. B. Giacobini, L. Olson et al.

      Pages 141-146

   4. Mechanisms of Intrauterine Growth Retardation: Role of Fetal and Maternal Hormones

      • P. D. Gluckman, J. E. Harding, M. H. Oliver, L. Liu, G. R. Ambler, M. Klempt et al.

      Pages 147-160

   5. Growth Hormone Treatment of Children with Intrauterine Growth Retardation

      • P. Czernichow, R. Rappaport

      Pages 161-170

5. Plenary Lecture

   1. Front Matter

      Pages 171-171

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The various congresses on growth hormone (GH) which have been held in Milan since 1967, the Milan Congresses, have witnessed over 25 years the tremendous expansion of a research field that was based initially upon the scarce knowledge of the biological properties of a protein. GH, whose chemical structure had just been identified and a radioimmunoassay developed for its measurement in blood, became in the following years a major area of biological research. The boundaries have since become blurred, as the research area has extended to the physiology and pathology of growth, puberty and reproduction, and the control of metabolism during the whole lifespan. Since the last GH Congress held in 1987, GH studies using the molecular biological approach have resulted in the puri­ fication, cloning and expression of the human GH (hGH) recep­ tor and binding protein, in new and exciting information on the insulin-like growth factors (IGF) and their paracrine and autocrine roles, and in the awareness that a panoply of binding proteins are present in the extracellular fluids and can, possibly, modulate IGF-receptor interactions and, thus, IGF actions. Finally, the availability of large amounts of biosynthetic hGH, besides allow­ ing more extensive clinical use in states of GH deficiency and extrasomatotrophic pathologies, has permitted disclosure of im­ portant metabolic effects of hGH during adulthood and, perhaps, aging and in many protein catabolic states.

• G proteins
• Wachstumshormon
• biosynthesis
• growth
• growth factor
• growth hormone
• hormone
• hormone therapy
• insulin-like
• metabolism
• nutrition
• protein
• puberty
• somatomedins
• steroid

• Department of Pharmacology, School of Medicine, University of Milan, Milan, Italy

  Eugenio E. Müller, Vittorio Locatelli

• Pharmaco-biological Institute, University of Bari, Bari, Italy

  Daniela Cocchi

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