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Cytochrome P450

  • John B. Schenkman
  • Helmut Greim

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 105)

Table of contents

  1. Front Matter
    Pages I-XXXIV
  2. The Monooxygenase System

  3. The Monooxygenase Reactions

  4. Forms of Microsomal P450

    1. Front Matter
      Pages 209-209
    2. F. J. Gonzalez
      Pages 211-219
    3. Y. Funae, S. Imaoka
      Pages 221-238
    4. F. J. Gonzalez
      Pages 239-257
    5. J. F. Sinclair, P. R. Sinclair
      Pages 259-277
    6. J. J. Stegeman
      Pages 279-291
    7. F. Durst, I. Benveniste
      Pages 293-310
    8. R. Feyereisen
      Pages 311-324
    9. D. Sanglard, O. Käppeli
      Pages 325-349
    10. H. W. Strobel, D. J. Stralka, D. K. Hammond, T. White
      Pages 363-371
    11. M. Warner, J.-Å. Gustafsson
      Pages 387-397
    12. L. R. Schwarz, F. J. Wiebel
      Pages 399-413
  5. Modulation of Cytochrome P450 Levels

    1. Front Matter
      Pages 431-431
    2. A. K. Daly, J. R. Idle
      Pages 433-446
    3. R. Kato, Y. Yamazoe
      Pages 447-459
    4. L. S. Birnbaum
      Pages 477-492
    5. K. Sogawa, Y. Fujii-Kuriyama
      Pages 493-501
  6. Chemical Modification, Protein-Protein and Protein-Lipid Interaction

    1. Front Matter
      Pages 525-525
    2. J. B. Schenkman
      Pages 527-545
    3. J. Blanck, K. Ruckpaul
      Pages 581-597
  7. Biosynthetic Forms of Cytochrome P450

    1. Front Matter
      Pages 599-599
    2. K. Okuda, T. Ogishima, M. Noshiro
      Pages 601-610
    3. E. R. Simpson, M. S. Mahendroo, G. D. Means, M. W. Kilgore, C. J. Corbin, C. R. Mendelson
      Pages 611-625
    4. P. C. White, K. M. Curnow, L. Pascoe
      Pages 641-650

About this book

Introduction

In this book the editors have brought together the widest group of investigators of the cytochrome P450 superfamily in order to present complete and right up-to-date coverage of this important enzyme system. The authors describe and analyze the components of the enzyme system, the reaction mechanisms involved, and the evolution and nomenclature of this superfamily of enzymes. They also describe the hepatic microsomal enzyme in a large number of species, from mammalian to birds and fish, to plants and unicellular organisms. The different P450 forms in different tissues of the mammalian system are also treated. Regulatory factors of P450 expression receive considerable attention, as do studies on the mechanism of interaction of the microsomal monooxygenase system components. Of particular interest to the reader are, for the first time, a compilation of chapters dedicated to forms of cytochrome P450 involved in steroid hormone biosynthesis. This volume presents the most complete survey of the cytochrome P450 field. It will allow recognition and understanding of the very wide implications this enzyme system has on life processes.

Keywords

biosynthesis cytochrome P450 enzyme enzymes hormone hormones steroid synthesis

Editors and affiliations

  • John B. Schenkman
    • 1
  • Helmut Greim
    • 2
  1. 1.Department of Pharmacology, MC 1505University of Connecticut Health CenterFarmingtonUSA
  2. 2.Institut für ToxikologieGesellschaft für Strahlen- und Umweltforschung mbHNeuherbergFed. Rep. of Germany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-77763-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 1993
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-77765-3
  • Online ISBN 978-3-642-77763-9
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site