DNA Replication: The Regulatory Mechanisms

1. Front Matter

   Pages I-XX

   PDF

2. Introduction

   1. Regulation of Initiation of Chromosome Replication

      • Arthur Kornberg

      Pages 1-10

3. Cellular DNA Replication

   1. Cell cycle control of DNA replication

      1. <i>Escherichia coli</i> Strains in Which the Chromosome Is Replicated from Origins Other than <i>oriC</i>

         • Rolf Bernander, Santanu Dasgupta, Kurt Nordström

         Pages 11-21

      2. Dam Methyltransferase in <i>Escherichia coli</i>: Effects of Different Enzymatic Levels on DNA Replication and Cell Growth

         • Erik Boye, Anita Lyngstadaas, Anders Løbner-Olesen

         Pages 23-35

      3. Further Characterization of a DNA Replication Inhibitor from the Cell Membrane of <i>Escherichia coli</i>

         • Patrick Hughes, Abderrahim Malki, John Herrick, Renée Kern, Masamichi Kohiyama

         Pages 37-48

      4. The Involvement of cdc2 in Cell Cycle Control of DNA Replication in Xenopus Egg Extracts

         • J. Julian Blow, Paul Nurse

         Pages 49-58

      5. A Gene of <i>Saccharomyces cerevisiae</i> Probably Involved in the Coordination of Chromatin Replication and Cell Division

         • Ulrike Wintersberger, Anneliese Karwan

         Pages 59-71

   2. Origin identification in mammalian chromosomes

      1. Origins of DNA Replication and Nucleosome Segregation in Mammalian Chromosomes

         • William C. Burhans, Lyubomir T. Vassilev, Jiarui Wu, José M. Sogo, Ferez S. Nallaseth, Melvin L. DePamphilis

         Pages 73-82

      2. Directions of DNA Replication in Yeast and Mammalian Cells

         • Joel A. Huberman, Dharani D. Dubey, Kevin A. Nawotka, George Russev, J. Aquiles Sanchez, Yeup Yoon et al.

         Pages 83-95

      3. The Curious Case of the Novel 2-D Gel Artifact

         • Bonita J. Brewer

         Pages 97-106

   3. Origin structure. function and modification

      1. Structural and Functional Characteristics of Autonomously Replicating Mammalian Origin-Enriched Sequences (<u>ORS</u>)

         • M. Zannis-Hadjopoulos, C. E. Pearson, D. Bell, D. Mah, M. McAlear, G. B. Price

         Pages 107-116

      2. Mutations Affecting Replication Origin Function in Yeast

         • Stephen E. Kearsey, David Kipling

         Pages 117-127

      3. Role of Transcriptional Elements in Activating Origins of Replication

         • Zong-Sheng Guo, Maria Wiekowski, Sadhan Majumder, Miriam Miranda, Melvin L. DePamphilis

         Pages 129-138

      4. Telomere Replication in <i>Saccharomyces cerevisiae</i>

         • V. A. Zakian, S.-S. Wang, R. Wellinger

         Pages 139-150

   4. Initiator — replication origin recognition

      1. The Role of DnaA-DnaA Box Interaction in Initiation of Chromosomal Replication in <i>Bacillus subtilis</i>

         • N. Ogasawara, S. Moriya, H. Yoshikawa

         Pages 151-160

      2. DnaA Protein Mediated Transcription Termination in the GUA Operon of <i>Escherichia coli</i>

         • Christoph Schaefer, Andreas Holz, Walter Messer

         Pages 161-168

      3. Screens for Proteins Binding to the ARS Consensus Sequence

         • James F. Theis, Carol S. Newlon

         Pages 169-179

      4. Protein-DNA Interaction at Yeast Replication Origins: an ARS Consensus Binding Protein

         • J. F. X. Hofmann, S. M. Gasser

         Pages 181-191

      5. Genetic Analysis of the Roles of Yeast ARS Binding Factor I

         • P. R. Rhode, J. L. Campbell

         Pages 193-204

      6. Proteins Involved in ARS Function in Yeast

         • B. K. Tye, V. Chang, C. Christ, R. Elble, S. Gibson, S. Passmore et al.

         Pages 205-213

DNA replication is a key event in the cell cycle. Although our knowledge is far from complete and many elusive regulatory mechanisms still remain beyondour grasp, many enzymes and a multiplicity of biochemical mechanisms involved have been discovered. Recent findings in E. coli have confirmed and yet surpassed the original hypothesis of F. Jacob. In yeast and higher eucaryotes, the apparent redundancy in putative origins and initiators has made an estimation of the importance of each identified element difficult to access. In spite of well established methodologies - which are also described in the book - the origin identification in mammalian chromosomes is still a controversial subject. On the other hand, considerable advances have been made in our understanding of virus DNA replication and this continues to deepen and broaden our understanding of the controls of cellular DNA replication.

• ATP
• DNA
• cell
• cell cycle
• cell division
• cell membrane
• chromosome
• enzyme
• enzymes
• mutation
• protein
• proteins
• replication
• synthesis
• transcription

• Institut Jacques Monod, CNRS, Université Paris 7, Paris Cedex 05, France

  Patrick Hughes, Masamichi Kohiyama

• Institut für Biochemie, München 2, Germany

  Ellen Fanning

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